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    CAF40 CCR4-NOT core subunit CAF40 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAF40
    Official Full Name
    CCR4-NOT core subunit CAF40
    Primary source
    SGD:S000005232
    Locus tag
    YNL288W
    See related
    AllianceGenome:SGD:S000005232; FungiDB:YNL288W; VEuPathDB:YNL288W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of transcription elongation by RNA polymerase II. Part of CCR4-NOT core complex. Orthologous to human CNOT9 (CCR4-NOT transcription complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAF40 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (90303..91424)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pcl1p Neighboring gene ncRNA Neighboring gene coatomer subunit gamma Neighboring gene U2 snRNP complex subunit CUS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. Russell P, et al. J Mol Biol, 2002 Sep 6. PMID 12215412
    2. Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes. Cui Y, et al. Mol Genet Genomics, 2008 Apr. PMID 18214544
    3. Specific roles for the Ccr4-Not complex subunits in expression of the genome. Azzouz N, et al. RNA, 2009 Mar. PMID 19155328, Free PMC Article
    4. Ccr4-Not and TFIIS Function Cooperatively To Rescue Arrested RNA Polymerase II. Dutta A, et al. Mol Cell Biol, 2015 Jun 1. PMID 25776559, Free PMC Article
    5. Insights into the structure of the CCR4-NOT complex by electron microscopy. Nasertorabi F, et al. FEBS Lett, 2011 Jul 21. PMID 21669201, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit CAF40
    NP_014111.1
    • Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      90303..91424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183126.1 → NP_014111.1  TPA: CCR4-NOT core subunit CAF40 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q5, P53829
      UniProtKB/TrEMBL
      A6ZSJ0, B3LPC6, B5VQC9, C7GS51, C8ZGN3, N1NYB3
      Conserved Domains (1) summary
      COG5209
      Location:30 → 373
      RCD1; Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53829.1

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