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    RBG2 Rbg2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RBG2
    Official Full Name
    Rbg2p
    Primary source
    SGD:S000003405
    Locus tag
    YGR173W
    See related
    AllianceGenome:SGD:S000003405; FungiDB:YGR173W; VEuPathDB:YGR173W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIR1
    Summary
    Predicted to enable GTP binding activity. Involved in cytoplasmic translation and positive regulation of cellular response to amino acid starvation. Located in cytoplasm. Orthologous to human DRG2 (developmentally regulated GTP binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RBG2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (843854..844960)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene transporter YIP1 Neighboring gene tRNA-Gly Neighboring gene Cbp4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
    2. Structure of Gcn1 bound to stalled and colliding 80S ribosomes. Pochopien AA, et al. Proc Natl Acad Sci U S A, 2021 Apr 6. PMID 33790014, Free PMC Article
    3. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Zeng F, et al. Cell Rep, 2021 Oct 26. PMID 34706231, Free PMC Article
    4. DRG represents a family of two closely related GTP-binding proteins. Li B, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760581
    5. Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress. Milgrom E, et al. J Biol Chem, 2007 Mar 9. PMID 17215245

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rbg2p
    NP_011689.1
    • Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      843854..844960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181302.1 → NP_011689.1  TPA: Rbg2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011689.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV7, P53295
      UniProtKB/TrEMBL
      A6ZUI5, B3LI57, C7GQ80, C8Z969, G2WEQ4, N1P469
      Conserved Domains (1) summary
      COG1163
      Location:1 → 368
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53295.1

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