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    Dctpp1 dCTP pyrophosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dctpp1provided by MGI
    Official Full Name
    dCTP pyrophosphatase 1provided by MGI
    Primary source
    MGI:MGI:1913672
    See related
    Ensembl:ENSMUSG00000042462 AllianceGenome:MGI:1913672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RS21-C6; 2410015N17Rik
    Summary
    Enables several functions, including identical protein binding activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in nucleoside triphosphate catabolic process. Located in cytosol. Is expressed in several structures, including brain ventricular layer; gut; jaw; lung; and vertebral axis musculature. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 40.4), liver E14.5 (RPKM 38.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dctpp1 in Genome Data Viewer
    Location:
    7 F3; 7 69.42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126856131..126859839, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127256959..127260667, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene selenophosphate synthetase 2 Neighboring gene ribosomal protein, large, P1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. Nonaka M, et al. FEBS J, 2009 Mar. PMID 19220460
    2. Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. Wu B, et al. J Mol Biol, 2007 Apr 13. PMID 17320107
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Several key residues involved in the substrate binding of RS21-C6 have been identified.
      Title: Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dCTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dCTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dCTP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside triphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside triphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrimidine deoxyribonucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA protection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA protection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA protection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dCTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dCTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dCTP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside triphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside triphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dCTP pyrophosphatase 1
    Names
    XTP3-transactivated gene A protein homolog
    dCTPase 1
    deoxycytidine-triphosphatase 1
    NP_075692.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023203.1 → NP_075692.1  dCTP pyrophosphatase 1

      See identical proteins and their annotated locations for NP_075692.1

      Status: PROVISIONAL

      Source sequence(s)
      AF110764
      Consensus CDS
      CCDS21862.1
      UniProtKB/Swiss-Prot
      Q9QY93
      Related
      ENSMUSP00000047845.5, ENSMUST00000035276.5
      Conserved Domains (1) summary
      cd11537
      Location:35 → 125
      NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126856131..126859839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QY93.1 GenPept UniProtKB/Swiss-Prot:Q9QY93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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