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    Cryge crystallin, gamma E [ Mus musculus (house mouse) ]

    Gene ID: 12968, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crygeprovided by MGI
    Official Full Name
    crystallin, gamma Eprovided by MGI
    Primary source
    MGI:MGI:88525
    See related
    Ensembl:ENSMUSG00000070870 AllianceGenome:MGI:88525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Elo; Cryg-2; Cryg-6; DGcry-2
    Summary
    Predicted to be a structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye. Is expressed in several structures, including central nervous system; eye; gonad; and gut gland. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 1.7), testis adult (RPKM 0.5) and 3 other tissues See more
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    Genomic context

    See Cryge in Genome Data Viewer
    Location:
    1 C2; 1 32.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65087716..65090783, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65048555..65051816, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24788 Neighboring gene aldo-keto reductase family 1, member C-like Neighboring gene translation machinery associated 16 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01169 Neighboring gene STARR-seq mESC enhancer starr_01170 Neighboring gene STARR-seq mESC enhancer starr_01171 Neighboring gene STARR-seq mESC enhancer starr_01172 Neighboring gene STARR-seq mESC enhancer starr_01173 Neighboring gene crystallin, gamma D Neighboring gene crystallin, gamma C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90717

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gamma-crystallin E
    Names
    eye lens obsolescence
    gamma-E-crystallin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420083.1NP_001407012.1  gamma-crystallin E isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158958
    2. NM_007777.4NP_031803.3  gamma-crystallin E isoform 1

      See identical proteins and their annotated locations for NP_031803.3

      Status: VALIDATED

      Source sequence(s)
      AC158958
      Consensus CDS
      CCDS35598.1
      UniProtKB/Swiss-Prot
      O89028, P26999, Q03740, Q9CXK5
      UniProtKB/TrEMBL
      A2RTH4
      Related
      ENSMUSP00000084617.6, ENSMUST00000087359.6
      Conserved Domains (2) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65087716..65090783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)