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    NR4A2 nuclear receptor subfamily 4 group A member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540245, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NR4A2provided by VGNC
    Official Full Name
    nuclear receptor subfamily 4 group A member 2provided by VGNC
    Primary source
    VGNC:VGNC:32246
    See related
    BGD:BT15931; Ensembl:ENSBTAG00000003650
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NR4A2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (39888135..39906254)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate dehydrogenase 2 Neighboring gene uncharacterized LOC132342968 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112443647

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139338

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to corticotropin-releasing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor subfamily 4 group A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076208.1 → NP_001069676.1  nuclear receptor subfamily 4 group A member 2

      See identical proteins and their annotated locations for NP_001069676.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123415
      UniProtKB/Swiss-Prot
      Q08E53
      UniProtKB/TrEMBL
      A0AAA9RZR9
      Related
      ENSBTAP00070037865.1, ENSBTAT00070063108.1
      Conserved Domains (2) summary
      cd07071
      Location:361 → 598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261 → 335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      39888135..39906254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876160.1 → XP_059732143.1  nuclear receptor subfamily 4 group A member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q08E53
      UniProtKB/TrEMBL
      A0AAA9RZR9

    2. XM_059876161.1 → XP_059732144.1  nuclear receptor subfamily 4 group A member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q08E53
      UniProtKB/TrEMBL
      A0AAA9RZR9
      Related
      ENSBTAP00070037832.1, ENSBTAT00070063065.1

    3. XM_005202480.5 → XP_005202537.1  nuclear receptor subfamily 4 group A member 2 isoform X3

      UniProtKB/TrEMBL
      A0AAA9RZR9
      Conserved Domains (2) summary
      cd06969
      Location:272 → 346
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      cl11397
      Location:373 → 584
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    4. XM_005202481.5 → XP_005202538.1  nuclear receptor subfamily 4 group A member 2 isoform X4

      See identical proteins and their annotated locations for XP_005202538.1

      UniProtKB/TrEMBL
      A0AAA9RZR9
      Conserved Domains (2) summary
      cd07071
      Location:298 → 535
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:198 → 272
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    5. XM_005202476.5 → XP_005202533.1  nuclear receptor subfamily 4 group A member 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RZR9, A0AAA9TX73
      Related
      ENSBTAP00070037844.1, ENSBTAT00070063081.1
      Conserved Domains (2) summary
      cd07071
      Location:372 → 609
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:272 → 346
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    6. XM_005202479.5 → XP_005202536.1  nuclear receptor subfamily 4 group A member 2 isoform X2

      See identical proteins and their annotated locations for XP_005202536.1

      UniProtKB/Swiss-Prot
      Q08E53
      UniProtKB/TrEMBL
      A0AAA9RZR9
      Conserved Domains (2) summary
      cd07071
      Location:361 → 598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261 → 335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    7. XM_005202477.4 → XP_005202534.1  nuclear receptor subfamily 4 group A member 2 isoform X2

      See identical proteins and their annotated locations for XP_005202534.1

      UniProtKB/Swiss-Prot
      Q08E53
      UniProtKB/TrEMBL
      A0AAA9RZR9
      Conserved Domains (2) summary
      cd07071
      Location:361 → 598
      NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:261 → 335
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

    RNA

    1. XR_001502187.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08E53.1 GenPept UniProtKB/Swiss-Prot:Q08E53

    Gene LinkOut

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