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    BPI bactericidal permeability increasing protein [ Bos taurus (domestic cattle) ]

    Gene ID: 280734, updated on 29-Jan-2025

    Summary

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    Official Symbol
    BPIprovided by VGNC
    Official Full Name
    bactericidal permeability increasing proteinprovided by VGNC
    Primary source
    VGNC:VGNC:97246
    See related
    BGD:BT10829; Ensembl:ENSBTAG00000014046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BPI in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (67153977..67201888)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC104973875 Neighboring gene KIAA1755 Neighboring gene lipopolysaccharide binding protein Neighboring gene lipopolysaccharide-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Association analysis of bovine bactericidal/permeability-increasing protein gene polymorphisms with somatic cell score in Holstein cattle. Connor EE, et al. Anim Genet, 2008 Aug. PMID 18492132
    2. Nucleotide sequence of the bovine bactericidal permeability increasing protein (BPI). Leong SR, et al. Nucleic Acids Res, 1990 May 25. PMID 2349103, Free PMC Article
    3. Phylogenetic and evolutionary analysis of the PLUNC gene family. Bingle CD, et al. Protein Sci, 2004 Feb. PMID 14739326, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymorphism in BPI has no effect on daughter yield deviation for somatic cell score in Holstein cattle.
      Title: Association analysis of bovine bactericidal/permeability-increasing protein gene polymorphisms with somatic cell score in Holstein cattle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bactericidal permeability-increasing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173895.2 → NP_776320.1  bactericidal permeability-increasing protein precursor

      See identical proteins and their annotated locations for NP_776320.1

      Status: PROVISIONAL

      Source sequence(s)
      X52563
      UniProtKB/TrEMBL
      A0AAA9SKP3
      Conserved Domains (2) summary
      smart00328
      Location:34 → 259
      BPI1; BPI/LBP/CETP N-terminal domain
      pfam02886
      Location:244 → 481
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      67153977..67201888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025000258.2 → XP_024856026.1  bactericidal permeability-increasing protein isoform X1

      UniProtKB/Swiss-Prot
      P17453, Q3T0P4
      UniProtKB/TrEMBL
      A0AAA9SKP3
      Related
      ENSBTAP00070048999.1, ENSBTAT00070080846.1
      Conserved Domains (2) summary
      smart00328
      Location:34 → 259
      BPI1; BPI/LBP/CETP N-terminal domain
      pfam02886
      Location:244 → 481
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

    2. XM_025000257.2 → XP_024856025.1  bactericidal permeability-increasing protein isoform X1

      UniProtKB/Swiss-Prot
      P17453, Q3T0P4
      UniProtKB/TrEMBL
      A0AAA9SKP3
      Related
      ENSBTAP00070048989.1, ENSBTAT00070080836.1
      Conserved Domains (2) summary
      smart00328
      Location:34 → 259
      BPI1; BPI/LBP/CETP N-terminal domain
      pfam02886
      Location:244 → 481
      LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17453.2 GenPept UniProtKB/Swiss-Prot:P17453

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.