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    TNPO2 transportin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 504589, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TNPO2provided by VGNC
    Official Full Name
    transportin 2provided by VGNC
    Primary source
    VGNC:VGNC:36200
    See related
    BGD:BT29658; EnsemblRapid:ENSBTAG00070015633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TNPO2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (12787586..12805878)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene telomerase RNA component interacting RNase Neighboring gene small nucleolar RNA SNORD41 Neighboring gene small nucleolar RNA ZL2 Neighboring gene F-box and WD repeat domain containing 9 Neighboring gene G protein subunit gamma 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC137497

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transportin-2
    Names
    transportin 2 (importin 3, karyopherin beta 2b)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205503.2 → NP_001192432.1  transportin-2

      See identical proteins and their annotated locations for NP_001192432.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000007
      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      12787586..12805878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005208656.5 → XP_005208713.1  transportin-2 isoform X2

      See identical proteins and their annotated locations for XP_005208713.1

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Related
      ENSBTAP00070020721.1, ENSBTAT00070035324.1
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    2. XM_024993912.2 → XP_024849680.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    3. XM_005208657.5 → XP_005208714.1  transportin-2 isoform X2

      See identical proteins and their annotated locations for XP_005208714.1

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    4. XM_010806720.4 → XP_010805022.1  transportin-2 isoform X2

      See identical proteins and their annotated locations for XP_010805022.1

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    5. XM_024993913.2 → XP_024849681.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    6. XM_024993909.2 → XP_024849677.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    7. XM_024993911.2 → XP_024849679.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1ND94
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    8. XM_059887968.1 → XP_059743951.1  transportin-2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1ND94

    9. XM_059887966.1 → XP_059743949.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1ND94

    10. XM_005208659.5 → XP_005208716.1  transportin-2 isoform X1

      See identical proteins and their annotated locations for XP_005208716.1

      UniProtKB/TrEMBL
      A0A3Q1MEC9
      Related
      ENSBTAP00070020706.1, ENSBTAT00070035294.1
      Conserved Domains (5) summary
      COG5215
      Location:117 → 851
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      cd00020
      Location:220 → 335
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam03810
      Location:127 → 194
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:503 → 557
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:188 → 209
      HEAT; HEAT repeat [structural motif]

    11. XM_059887967.1 → XP_059743950.1  transportin-2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1ND94

    RNA

    1. XR_009495056.1 RNA Sequence

      Related
      ENSBTAT00070035314.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045891.1: Suppressed sequence

      Description
      NM_001045891.1: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials