U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 512171, updated on 30-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ADAMTS1provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 1provided by VGNC
    Primary source
    VGNC:VGNC:25614
    See related
    BGD:BT21164; EnsemblRapid:ENSBTAG00070002498
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADAMTS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (9583735..9592432)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA51 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 5 Neighboring gene uncharacterized LOC112448297 Neighboring gene cysteine and tyrosine rich 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization and transcriptional regulation of a disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) in bovine preovulatory follicles. Sayasith K, et al. Endocrinology, 2013 Aug. PMID 23751874
    2. Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation. Mishra B, et al. Domest Anim Endocrinol, 2013 Jul. PMID 23751571
    3. MicroRNA-375 regulates oocyte in vitro maturation by targeting ADAMTS1 and PGR in bovine cumulus cells. Zhang J, et al. Biomed Pharmacother, 2019 Oct. PMID 31545267
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-375 represses oocyte in vitro maturation at least partially through targeting ADAMTS1 and PGR in cumulus cells.
      Title: MicroRNA-375 regulates oocyte in vitro maturation by targeting ADAMTS1 and PGR in bovine cumulus cells.
    2. study indicates that disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) participates in bovine endometrial remodeling
      Title: Expression of ADAMTS1 mRNA in bovine endometrium and placenta during gestation.
    3. Data indicate that ADAMTS1 promoter activity and mRNA expression were increased by forskolin and human chorionic gonadotropin.
      Title: Molecular characterization and transcriptional regulation of a disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) in bovine preovulatory follicles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101080.1 → NP_001094550.1  A disintegrin and metalloproteinase with thrombospondin motifs 1

      See identical proteins and their annotated locations for NP_001094550.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151273
      UniProtKB/TrEMBL
      A0AAA9SLK9, A7MB07
      Related
      ENSBTAP00070003374.1, ENSBTAT00070005791.1
      Conserved Domains (6) summary
      smart00209
      Location:565 → 617
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:261 → 466
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:261 → 470
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:67 → 165
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:728 → 845
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:456 → 550
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9583735..9592432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.