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    CACNA1D calcium voltage-gated channel subunit alpha1 D [ Bos taurus (domestic cattle) ]

    Gene ID: 408013, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CACNA1Dprovided by VGNC
    Official Full Name
    calcium voltage-gated channel subunit alpha1 Dprovided by VGNC
    Primary source
    VGNC:VGNC:26674
    See related
    BGD:BT10231; Ensembl:ENSBTAG00000010026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See CACNA1D in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (47138335..47508935, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene actin related protein 8 Neighboring gene interleukin 17 receptor B Neighboring gene choline dehydrogenase Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated proteins 1A/1B light chain 3B-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion. Enyeart JJ, et al. Am J Physiol Cell Physiol, 2015 Jun 1. PMID 25788571, Free PMC Article
    2. Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation. Peruffo A, et al. Neurosci Lett, 2013 Nov 27. PMID 24148303
    3. Differential expression of calcium channel subtypes in the bovine adrenal medulla. García-Palomero E, et al. Neuroendocrinology, 2001 Oct. PMID 11598381
    4. Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture. Benavides A, et al. Neuroscience, 2004. PMID 15450357
    5. Greater diversity than previously thought of chromaffin cell Ca2+ channels, derived from mRNA identification studies. García-Palomero E, et al. FEBS Lett, 2000 Sep 22. PMID 11007970

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adrenal fasciculata cells express Cav1.3 and Cav3.2 calcium channels that regulate cortisol secretion.
      Title: Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
    2. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.
      Title: Expression profile of the pore-forming subunits α1A and α1D in the foetal bovine hypothalamus: a mammal with a long gestation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit alpha-1D
    Names
    voltage-gated calcium channel alpha 1D subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193025.1 → NP_001179954.1  voltage-dependent L-type calcium channel subunit alpha-1D

      See identical proteins and their annotated locations for NP_001179954.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000022
      UniProtKB/TrEMBL
      A0AAA9SN11, F1MTK5
      Related
      ENSBTAP00000013226.5, ENSBTAT00000013226.7
      Conserved Domains (4) summary
      pfam00520
      Location:143 → 417
      Ion_trans; Ion transport protein
      pfam08763
      Location:1568 → 1639
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1663 → 2180
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1503 → 1566
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      47138335..47508935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010817680.3 → XP_010815982.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

      UniProtKB/TrEMBL
      A0AAA9S1S2
      Conserved Domains (4) summary
      pfam00520
      Location:1222 → 1460
      Ion_trans; Ion transport protein
      pfam08763
      Location:1533 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1628 → 2145
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1468 → 1531
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. XM_059879485.1 → XP_059735468.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

      UniProtKB/TrEMBL
      A0AAA9SN11

    3. XM_059879486.1 → XP_059735469.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

      UniProtKB/TrEMBL
      A0AAA9S1S2

    4. XM_010817677.3 → XP_010815979.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

      UniProtKB/TrEMBL
      A0AAA9S1S2
      Conserved Domains (4) summary
      pfam00520
      Location:1242 → 1480
      Ion_trans; Ion transport protein
      pfam08763
      Location:1553 → 1624
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1648 → 2165
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1488 → 1551
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. XM_059879483.1 → XP_059735466.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

      UniProtKB/TrEMBL
      A0AAA9S1S2

    6. XM_010817674.3 → XP_010815976.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

      UniProtKB/TrEMBL
      A0AAA9SN11
      Conserved Domains (4) summary
      pfam00520
      Location:143 → 417
      Ion_trans; Ion transport protein
      pfam08763
      Location:1568 → 1639
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1663 → 2180
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1503 → 1566
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. XM_059879484.1 → XP_059735467.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

      UniProtKB/TrEMBL
      A0AAA9S1S2

    8. XM_059879482.1 → XP_059735465.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

      UniProtKB/TrEMBL
      A0AAA9SN11, F1MTK5

    9. XM_059879487.1 → XP_059735470.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

      UniProtKB/TrEMBL
      A0AAA9S1S2

    10. XM_005222722.5 → XP_005222779.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

      See identical proteins and their annotated locations for XP_005222779.1

      UniProtKB/TrEMBL
      A0AAA9S1S2, A0AAA9T3Y9
      Related
      ENSBTAP00000090413.1, ENSBTAT00000127898.1
      Conserved Domains (4) summary
      pfam00520
      Location:1222 → 1460
      Ion_trans; Ion transport protein
      pfam08763
      Location:1533 → 1604
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1628 → 2136
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1468 → 1531
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. XM_059879481.1 → XP_059735464.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

      UniProtKB/TrEMBL
      A0AAA9SN11, A0AAA9TTJ8
      Related
      ENSBTAP00000101954.1, ENSBTAT00000130707.1
    Nucleotide Protein Strain
    Heading Accession and Version

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