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    APP amyloid beta precursor protein [ Bos taurus (domestic cattle) ]

    Gene ID: 280722, updated on 30-Jan-2025

    Summary

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    Official Symbol
    APPprovided by VGNC
    Official Full Name
    amyloid beta precursor proteinprovided by VGNC
    Primary source
    VGNC:VGNC:26038
    See related
    BGD:BT10571; EnsemblRapid:ENSBTAG00070005236
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See APP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (10231769..10543975)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107132174 Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene U6 spliceosomal RNA Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene junctional adhesion molecule 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Characterization of Amyloid-β Deposits in Bovine Brains. Vallino Costassa E, et al. J Alzheimers Dis, 2016. PMID 26890772, Free PMC Article
    2. The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids. Tashima Y, et al. J Biol Chem, 2004 Apr 23. PMID 14709559
    3. Re-sequencing of DNA from a diverse panel of cattle reveals a high level of polymorphism in both intron and exon. Konfortov BA, et al. Mamm Genome, 1999 Dec. PMID 10594237
    4. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Johnstone EM, et al. Brain Res Mol Brain Res, 1991 Jul. PMID 1656157
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid-beta precursor protein
    Names
    ABPP
    alzheimer disease amyloid A4 protein homolog
    amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
    amyloid beta A4 protein
    amyloid precursor protein
    amyloid-beta (A4) precursor protein
    beta-amyloid precursor protein
    protease nexin-II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076796.1 → NP_001070264.1  amyloid-beta precursor protein precursor

      See identical proteins and their annotated locations for NP_001070264.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123413
      UniProtKB/TrEMBL
      A0A3Q1MI56, F1N2T4, Q08E54
      Related
      ENSBTAP00070006769.1, ENSBTAT00070012005.1
      Conserved Domains (6) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:600 → 638
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:641 → 691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291 → 473
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10231769..10543975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005201137.4 → XP_005201194.1  amyloid-beta precursor protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUG2, A0A3Q1MI56
      Related
      ENSBTAP00070006759.1, ENSBTAT00070011985.1
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:675 → 713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716 → 766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:366 → 548
      APP_E2; E2 domain of amyloid precursor protein

    2. XM_005201138.4 → XP_005201195.1  amyloid-beta precursor protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MI56, A0A3Q1MLQ6
      Related
      ENSBTAP00070006765.1, ENSBTAT00070011997.1
      Conserved Domains (7) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657 → 695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698 → 748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366 → 548
      APP_E2; E2 domain of amyloid precursor protein

    3. XM_005201139.4 → XP_005201196.1  amyloid-beta precursor protein isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MGE4, A0A3Q1MI56
      Related
      ENSBTAP00070006762.1, ENSBTAT00070011991.1
      Conserved Domains (7) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656 → 694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697 → 747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347 → 529
      APP_E2; E2 domain of amyloid precursor protein

    4. XM_005201140.4 → XP_005201197.1  amyloid-beta precursor protein isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MI56
      Conserved Domains (7) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638 → 676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679 → 729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347 → 529
      APP_E2; E2 domain of amyloid precursor protein

    5. XM_010800926.3 → XP_010799228.1  amyloid-beta precursor protein isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MI56, A0A3S5ZPG2
      Related
      ENSBTAP00070006750.1, ENSBTAT00070011968.1
      Conserved Domains (6) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:619 → 657
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:660 → 710
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:310 → 492
      APP_E2; E2 domain of amyloid precursor protein

    6. XM_005201141.3 → XP_005201198.1  amyloid-beta precursor protein isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MI56
      Conserved Domains (6) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:582 → 620
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:623 → 673
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291 → 473
      APP_E2; E2 domain of amyloid precursor protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28053.1 GenPept UniProtKB/Swiss-Prot:Q28053

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