STAT3 signal transducer and activator of transcription 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: STAT3provided by VGNC
Official Full Name: signal transducer and activator of transcription 3provided by VGNC
Primary source: VGNC:VGNC:35371
See related: BGD:BT11963; EnsemblRapid:ENSBTAG00070022967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (42417946..42491782, complement)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together these studies represent the first investigation of STAT3 signaling that directly influence miR-21 expression in bovine oocytes and cumulus cells.
Title: STAT3 signaling stimulates miR-21 expression in bovine cumulus cells during in vitro oocyte maturation.
variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.
Title: Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle.
Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
Title: Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
Title: Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Title: Identification of single nucleotide polymorphisms of the signal transducer and activator of transcription 3 gene (STAT3) associated with body measurement and carcass quality traits in beef cattle.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
Title: Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle.
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.
Title: Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.
role of shear flow in attenuating activation in endothelial cells
Title: Shear flow attenuates serum-induced STAT3 activation in endothelial cells.
results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
Title: JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.
peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3
Title: Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

PMC303343P1 (e-PCR)
- UniSTS:272501

PMC317074P1 (e-PCR)
- UniSTS:273070

BMS739 (e-PCR), detects polymorphism
- UniSTS:15050

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: signal transducer and activator of transcription 3

Names: signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012671.2 → NP_001012689.2 signal transducer and activator of transcription 3

See identical proteins and their annotated locations for NP_001012689.2

Status: VALIDATED

Source sequence(s)

AJ620655, BC109481

UniProtKB/Swiss-Prot

P61635

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 319

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:321 → 573

STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

42417946..42491782 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024979867.2 → XP_024835635.1 signal transducer and activator of transcription 3 isoform X4

UniProtKB/Swiss-Prot

P61635

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 319

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:321 → 573

STAT_bind; STAT protein, DNA binding domain
XM_010816228.4 → XP_010814530.1 signal transducer and activator of transcription 3 isoform X2

UniProtKB/Swiss-Prot

P61635

Related

ENSBTAP00070031121.1, ENSBTAT00070051822.1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 319

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:321 → 573

STAT_bind; STAT protein, DNA binding domain
XM_024979866.2 → XP_024835634.1 signal transducer and activator of transcription 3 isoform X3

UniProtKB/Swiss-Prot

P61635

UniProtKB/TrEMBL

Q32LP6

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 319

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:321 → 573

STAT_bind; STAT protein, DNA binding domain
XM_024979865.2 → XP_024835633.1 signal transducer and activator of transcription 3 isoform X1

UniProtKB/Swiss-Prot

P61635

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 319

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:321 → 573

STAT_bind; STAT protein, DNA binding domain