PLCG1 phospholipase C gamma 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PLCG1provided by VGNC
Official Full Name: phospholipase C gamma 1provided by VGNC
Primary source: VGNC:VGNC:32988
See related: BGD:BT10117; Ensembl:ENSBTAG00000017584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (69790995..69822905)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain.
Title: Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.
Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2+ flux, NF-AT and AP-1 activation.
Title: A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling.
This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.
Title: The tyrosine [correction of tryrosine] phosphorylation and cytoskeletal translocation of phospholipase C gamma 1 in bovine adrenal medullary chromaffin cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ksks435 (e-PCR)
- UniSTS:514492

D20S529E (e-PCR)
- UniSTS:31967

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Names: PLC-148; PLC-II; PLC-gamma-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C-II

NP_776850.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174425.3 → NP_776850.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

See identical proteins and their annotated locations for NP_776850.1

Status: PROVISIONAL

Source sequence(s)

Y00301

UniProtKB/Swiss-Prot

P08487

UniProtKB/TrEMBL

A0AAA9T7A8

Related

ENSBTAP00070046310.1, ENSBTAT00070075954.1

Conserved Domains (10) summary

smart00149
Location:954 → 1069

PLCYc; Phospholipase C, catalytic domain (part); domain Y

cd00275
Location:1087 → 1211

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08592
Location:319 → 466

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:663 → 765

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:545 → 649

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cd11970
Location:791 → 850

SH3_PLCgamma1; Src homology 3 domain of Phospholipase C (PLC) gamma 1

cd13234
Location:864 → 933

PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain

cd13362
Location:29 → 151

PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain

pfam00169
Location:71 → 142

PH; PH domain

cl17171
Location:489 → 523

PH-like; Pleckstrin homology-like domain