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    TOX2 TOX high mobility group box family member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 519845, updated on 29-Jan-2025

    Summary

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    Official Symbol
    TOX2provided by VGNC
    Official Full Name
    TOX high mobility group box family member 2provided by VGNC
    Primary source
    VGNC:VGNC:55084
    See related
    BGD:BT13107; Ensembl:ENSBTAG00000016741
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TOX2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (72414378..72567754)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-2284y-2 Neighboring gene microRNA mir-2285u Neighboring gene DET1- and DDB1-associated protein 1-like Neighboring gene junctophilin 2 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene oxidative stress responsive serine rich 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TOX high mobility group box family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206688.2 → NP_001193617.1  TOX high mobility group box family member 2 isoform 1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC149318, DV890700, EE251358, EH154557, NKLS02000013
      UniProtKB/TrEMBL
      A0AAA9TCY4
      Conserved Domains (1) summary
      cd00084
      Location:246 → 311
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    2. NM_001206689.1 → NP_001193618.1  TOX high mobility group box family member 2 isoform 2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC149318
      UniProtKB/TrEMBL
      A0A3Q1MK10
      Related
      ENSBTAP00070024526.1, ENSBTAT00070041094.1
      Conserved Domains (1) summary
      cd00084
      Location:246 → 311
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72414378..72567754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025000596.2 → XP_024856364.1  TOX high mobility group box family member 2 isoform X4

      UniProtKB/TrEMBL
      A0AAA9TCY4, F1MPI6
      Related
      ENSBTAP00070024530.1, ENSBTAT00070041101.1
      Conserved Domains (1) summary
      cd00084
      Location:224 → 289
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    2. XM_025000595.2 → XP_024856363.1  TOX high mobility group box family member 2 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TCY4, A0AAA9TGM8
      Related
      ENSBTAP00070024534.1, ENSBTAT00070041106.1
      Conserved Domains (2) summary
      cd00084
      Location:246 → 311
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl27427
      Location:406 → 474
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    3. XM_025000599.2 → XP_024856367.1  TOX high mobility group box family member 2 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TCY4
      Conserved Domains (1) summary
      cd00084
      Location:204 → 269
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    4. XM_059892609.1 → XP_059748592.1  TOX high mobility group box family member 2 isoform X6

      UniProtKB/TrEMBL
      A0AAA9TCY4

    5. XM_025000597.2 → XP_024856365.1  TOX high mobility group box family member 2 isoform X5

      UniProtKB/TrEMBL
      A0AAA9TCY4
      Conserved Domains (2) summary
      cd00084
      Location:221 → 286
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl27427
      Location:381 → 449
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    6. XM_025000593.2 → XP_024856361.1  TOX high mobility group box family member 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TCY4
      Conserved Domains (2) summary
      cd00084
      Location:290 → 355
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl27427
      Location:450 → 518
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

    7. XM_025000594.2 → XP_024856362.1  TOX high mobility group box family member 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TCY4
      Conserved Domains (2) summary
      cd00084
      Location:290 → 355
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl27427
      Location:450 → 518
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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