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    SELENOM selenoprotein M [ Bos taurus (domestic cattle) ]

    Gene ID: 787736, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SELENOMprovided by VGNC
    Official Full Name
    selenoprotein Mprovided by VGNC
    Primary source
    VGNC:VGNC:53920
    See related
    EnsemblRapid:ENSBTAG00070024136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SELM
    Summary
    The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016]
    Orthologs
    human mouse all
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    Genomic context

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    See SELENOM in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (69961539..69964345, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene smoothelin Neighboring gene inositol polyphosphate-5-phosphatase J Neighboring gene phospholipase A2 group III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs. Casey OM, et al. Biochim Biophys Acta, 2004 Jul 13. PMID 15245912
    2. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
    3. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
    4. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
    5. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selenoprotein M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163171.3 → NP_001156643.2  selenoprotein M precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the selenoprotein encoding transcript.
      Source sequence(s)
      BU917216, CO893319, DN539864
      Related
      ENSBTAP00070032570.1, ENSBTAT00070054380.1
      Conserved Domains (1) summary
      pfam08806
      Location:37 → 111
      Sep15_SelM; Sep15/SelM redox domain

    RNA

    1. NR_144761.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a novel exon in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BU917216, CO893319, DN539864, EE243442, NKLS02000017

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      69961539..69964345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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