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    FPGS folylpolyglutamate synthase [ Bos taurus (domestic cattle) ]

    Gene ID: 505809, updated on 27-Dec-2024

    Summary

    Official Symbol
    FPGSprovided by VGNC
    Official Full Name
    folylpolyglutamate synthaseprovided by VGNC
    Primary source
    VGNC:VGNC:55047
    See related
    Ensembl:ENSBTAG00000008994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    NEW
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    Genomic context

    See FPGS in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (98472685..98496940)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3C Neighboring gene cyclin dependent kinase 9 Neighboring gene endoglin Neighboring gene adenylate kinase 1

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    folylpolyglutamate synthase, mitochondrial
    Names
    folylpoly-gamma-glutamate synthetase
    tetrahydrofolate synthase
    tetrahydrofolylpolyglutamate synthase
    NP_001019651.2
    XP_024854162.1
    XP_024854163.1
    XP_024854164.1
    XP_024854165.1
    XP_024854167.1
    XP_059747060.1
    XP_059747061.1
    XP_059747062.1
    XP_059747063.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024480.2NP_001019651.2  folylpolyglutamate synthase, mitochondrial

      See identical proteins and their annotated locations for NP_001019651.2

      Status: VALIDATED

      Source sequence(s)
      BC146114, BE666530, CO888657
      UniProtKB/Swiss-Prot
      A6H751
      UniProtKB/TrEMBL
      A0AAA9SA81
      Related
      ENSBTAP00000011844.5, ENSBTAT00000011844.6
      Conserved Domains (2) summary
      PLN02881
      Location:41579
      PLN02881; tetrahydrofolylpolyglutamate synthase
      pfam02875
      Location:358439
      Mur_ligase_C; Mur ligase family, glutamate ligase domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      98472685..98496940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891078.1XP_059747061.1  folylpolyglutamate synthase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9SA81, F1MWN5
    2. XM_059891079.1XP_059747062.1  folylpolyglutamate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0AAA9T5R8, E1B859
    3. XM_024998397.2XP_024854165.1  folylpolyglutamate synthase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LK21, A0AAA9TGE6
      Related
      ENSBTAP00000059869.2, ENSBTAT00000085524.2
      Conserved Domains (1) summary
      cl27336
      Location:6543
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    4. XM_059891077.1XP_059747060.1  folylpolyglutamate synthase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9SA81, F1MWN5
    5. XM_059891080.1XP_059747063.1  folylpolyglutamate synthase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0AAA9SA81
    6. XM_024998394.2XP_024854162.1  folylpolyglutamate synthase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0AAA9TGE6
      Related
      ENSBTAP00000095946.1, ENSBTAT00000106397.1
      Conserved Domains (1) summary
      cl27336
      Location:16555
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    7. XM_024998399.2XP_024854167.1  folylpolyglutamate synthase, mitochondrial isoform X6

      Conserved Domains (1) summary
      cl27336
      Location:20466
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    8. XM_024998395.2XP_024854163.1  folylpolyglutamate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0AAA9T5R8, E1B859
      Conserved Domains (1) summary
      cl27336
      Location:12548
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
    9. XM_024998396.2XP_024854164.1  folylpolyglutamate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0AAA9T5R8, E1B859
      Related
      ENSBTAP00000032691.6, ENSBTAT00000032762.6
      Conserved Domains (1) summary
      cl27336
      Location:12548
      FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]