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    GLUD1 glutamate dehydrogenase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281785, updated on 30-Jan-2025

    Summary

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    Gene symbol
    GLUD1
    Gene description
    glutamate dehydrogenase 1
    See related
    BGD:BT13268; EnsemblRapid:ENSBTAG00070023325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GDH; GDH1; GDH 1
    Orthologs
    human mouse all
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    Genomic context

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    See GLUD1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (41609012..41649016, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 25 member A Neighboring gene adipogenesis regulatory factor Neighboring gene uncharacterized LOC112444758 Neighboring gene shieldin complex subunit 2 Neighboring gene synaptotagmin 15B Neighboring gene G protein regulated inducer of neurite outgrowth 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. Borgnia MJ, et al. Mol Pharmacol, 2016 Jun. PMID 27036132, Free PMC Article
    2. Studies of glutamate dehydrogenase: chemical modification and quantitative determination of tryptophan residues. Witzemann V, et al. Eur J Biochem, 1974 Apr 1. PMID 4365183
    3. Sequence of bovine liver glutamate dehydrogenase. 8. Peptides produced by specific chemical cleavages; the complete sequence of the protein. Moon K, et al. J Biol Chem, 1973 May 10. PMID 4735572
    4. Studies of glutamate dehydrogenase. Identification of an amino group involved in the substrate binding. Rasched I, et al. Eur J Biochem, 1974 Feb 1. PMID 4856315
    5. The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery. Peterson PE, et al. Structure, 1999 Jul 15. PMID 10425679

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. near-atomic resolution cryoelectron microscopy structures, at resolutions ranging from 3.2 A to 3.6 A for GDH complexes, is reported.
      Title: Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.
    2. Data show that glutamate dehydrogenase activity in an enzymatic catalyzed reaction by tracing the increasing of oxidation current of NADH.
      Title: Electrochemical and spectral study on the effects of Al(III) and nano-Al13 species on glutamate dehydrogenase activity.
    3. Data show that heat inactivation of the native GDH enzyme occurred with a rate constant of inactivation of 0.252 min-1.
      Title: Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation.
    4. the existence of two partially unfolded states of GDH at moderate acidic pHs which may be considered as molten and pre-molten globule-like states.
      Title: Partially folded conformations of bovine liver glutamate dehydrogenase induced by mild acidic conditions.
    5. Results showt superactivation is caused by cleavage at the N terminus of the protein and not the C-terminal allosteric site, as has previously been suggested.
      Title: The structural basis of proteolytic activation of bovine glutamate dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127177

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate dehydrogenase 1, mitochondrial
    NP_872593.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182652.2 → NP_872593.2  glutamate dehydrogenase 1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      EH203370, EV613592, EV620278, EV666679, EV667699, GH319363
      UniProtKB/Swiss-Prot
      P00366, Q3SYY0, Q7YS29, Q8HZ49
      UniProtKB/TrEMBL
      A0A140T871
      Related
      ENSBTAP00070031487.1, ENSBTAT00070052505.1
      Conserved Domains (3) summary
      cd01076
      Location:266 → 551
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      COG0334
      Location:85 → 551
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      pfam02812
      Location:116 → 243
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      41609012..41649016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00366.2 GenPept UniProtKB/Swiss-Prot:P00366

    Gene LinkOut

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