TOP1 DNA topoisomerase I [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TOP1provided by VGNC
Official Full Name: DNA topoisomerase Iprovided by VGNC
Primary source: VGNC:VGNC:49136
See related: BGD:BT10591; Ensembl:ENSBTAG00000007960
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (69684979..69780576)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nucleosomes represent a physical barrier for DNA topoisomerase I activity
Title: Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA topoisomerase 1

Names: topoisomerase (DNA) 1; topoisomerase (DNA) I

NP_001193416.1

EC 5.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206487.2 → NP_001193416.1 DNA topoisomerase 1

See identical proteins and their annotated locations for NP_001193416.1

Status: VALIDATED

Source sequence(s)

BC118461, DV927671, EE228015, EE351723, EE369776, EH133197, NKLS02000013

UniProtKB/TrEMBL

A0AAA9RVG1, A0AAA9TV68

Related

ENSBTAP00070046264.1, ENSBTAT00070075832.1

Conserved Domains (2) summary

smart00435
Location:364 → 741

TOPEUc; DNA Topoisomerase I (eukaryota)

cd03488
Location:220 → 434

Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...