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    MASP2 MBL associated serine protease 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 505819, updated on 29-Jan-2025

    Summary

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    Official Symbol
    MASP2provided by VGNC
    Official Full Name
    MBL associated serine protease 2provided by VGNC
    Primary source
    VGNC:VGNC:31256
    See related
    BGD:BT12156; Ensembl:ENSBTAG00000012808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MASP2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (42581910..42597203)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein Neighboring gene castor zinc finger 1 Neighboring gene peroxisomal biogenesis factor 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle. Wu J, et al. Genet Mol Res, 2015 Jan 15. PMID 25729929
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the combination of the BMAP-28 genotype CC and the MASP-2 genotype GG was the best one, in which the somatic cell score was significantly lower than those in the other combinations.
      Title: Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in complement activation, lectin pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannan-binding lectin serine protease 2
    Names
    mannan binding lectin serine peptidase 2
    NP_001179001.1
    XP_059731270.1
    XP_059731271.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192072.2 → NP_001179001.1  mannan-binding lectin serine protease 2 precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000016
      UniProtKB/TrEMBL
      A0AAA9T055, E1BJ49
      Related
      ENSBTAP00070023619.1, ENSBTAT00070040061.1
      Conserved Domains (6) summary
      smart00020
      Location:443 → 678
      Tryp_SPc; Trypsin-like serine protease
      smart00032
      Location:300 → 361
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00179
      Location:138 → 176
      EGF_CA; Calcium-binding EGF-like domain
      cd00041
      Location:184 → 295
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444 → 681
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00084
      Location:366 → 429
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42581910..42597203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059875287.1 → XP_059731270.1  mannan-binding lectin serine protease 2 isoform X1

    2. XM_059875288.1 → XP_059731271.1  mannan-binding lectin serine protease 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9S3R3
      Related
      ENSBTAP00070023598.1, ENSBTAT00070040040.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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