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    MAPK8 mitogen-activated protein kinase 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 539941, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MAPK8provided by VGNC
    Official Full Name
    mitogen-activated protein kinase 8provided by VGNC
    Primary source
    VGNC:VGNC:31223
    See related
    BGD:BT10854; Ensembl:ENSBTAG00000007876
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    JNK1
    Orthologs
    human mouse all
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    Genomic context

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    See MAPK8 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (42712811..42813456)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344152 Neighboring gene protein tyrosine phosphatase non-receptor type 20 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC132344153 Neighboring gene WDFY family member 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling. Panzhinskiy E, et al. Cardiovasc Res, 2012 Aug 1. PMID 22735370, Free PMC Article
    2. Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK. Karahashi H, et al. J Immunol, 2009 Jun 1. PMID 19454725, Free PMC Article
    3. Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide. Chen SC, et al. Atherosclerosis, 2008 Dec. PMID 18377912
    4. Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways. Kishore R, et al. Circ Res, 2003 Nov 14. PMID 14576193
    5. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. Zhang W, et al. J Biol Chem, 2005 May 13. PMID 15755722

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
      Title: Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling.
    2. ATF3 induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
      Title: Acute hypoxia to endothelial cells induces activating transcription factor 3 (ATF3) expression that is mediated via nitric oxide.
    3. JNK plays an important role in the induction of apoptosis in transformed bovine brain endothelial cells stimulated by LPS
      Title: Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK.
    4. PKD is a critical mediator in H2O2- but not TNF-induced ASK1-JNK signaling
      Title: Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor.
    5. These data suggest a differential requirement of JNK1 and p38 MAPK in TNF regulation of E2F1. Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF-mediated EC dysfunction.
      Title: Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 8
    NP_001179903.2
    XP_005226640.1
    XP_005226642.1
    XP_005226643.1
    XP_005226644.1
    XP_010819018.1
    XP_010819019.1
    XP_010819020.1
    XP_010819021.1
    XP_024842508.1
    XP_024842509.1
    XP_024842510.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192974.2 → NP_001179903.2  mitogen-activated protein kinase 8

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000028
      UniProtKB/TrEMBL
      F1MM73, Q05B47
      Related
      ENSBTAP00000010361.3, ENSBTAT00000010361.4
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42712811..42813456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986740.2 → XP_024842508.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    2. XM_010820717.4 → XP_010819019.1  mitogen-activated protein kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_010819019.1

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    3. XM_024986742.2 → XP_024842510.1  mitogen-activated protein kinase 8 isoform X7

      UniProtKB/TrEMBL
      F1MM73, Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    4. XM_010820718.4 → XP_010819020.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    5. XM_005226587.5 → XP_005226644.1  mitogen-activated protein kinase 8 isoform X8

      UniProtKB/TrEMBL
      A0AAA9S472, Q05B47
      Related
      ENSBTAP00000079922.1, ENSBTAT00000118937.1
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    6. XM_005226585.5 → XP_005226642.1  mitogen-activated protein kinase 8 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Related
      ENSBTAP00000072616.1, ENSBTAT00000084331.2
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    7. XM_010820716.4 → XP_010819018.1  mitogen-activated protein kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_010819018.1

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    8. XM_005226586.5 → XP_005226643.1  mitogen-activated protein kinase 8 isoform X7

      See identical proteins and their annotated locations for XP_005226643.1

      UniProtKB/TrEMBL
      F1MM73, Q05B47
      Conserved Domains (1) summary
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    9. XM_005226583.5 → XP_005226640.1  mitogen-activated protein kinase 8 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    10. XM_024986741.2 → XP_024842509.1  mitogen-activated protein kinase 8 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1NK45
      Conserved Domains (1) summary
      cd07850
      Location:1 → 284
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    11. XM_010820719.4 → XP_010819021.1  mitogen-activated protein kinase 8 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1NK45, A0AAA9TXN0
      Related
      ENSBTAP00000101408.1, ENSBTAT00000108406.1
      Conserved Domains (2) summary
      smart00220
      Location:26 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25 → 360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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