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    RARA retinoic acid receptor alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 534280, updated on 30-Jan-2025

    Summary

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    Official Symbol
    RARAprovided by VGNC
    Official Full Name
    retinoic acid receptor alphaprovided by VGNC
    Primary source
    VGNC:VGNC:33729
    See related
    BGD:BT16928; EnsemblRapid:ENSBTAG00070027666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See RARA in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (40551174..40595283)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family member 2 Neighboring gene cell division cycle 6 Neighboring gene gap junction protein delta 3 Neighboring gene large ribosomal subunit protein uL15-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Regulation of mammary gland sensitivity to thyroid hormones during the transition from pregnancy to lactation. Capuco AV, et al. Exp Biol Med (Maywood), 2008 Oct. PMID 18641053
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to corticotropin-releasing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinoic acid receptor alpha
    Names
    RAR-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014942.4 → NP_001014942.2  retinoic acid receptor alpha

      See identical proteins and their annotated locations for NP_001014942.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000019
      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3
      Conserved Domains (2) summary
      cd06937
      Location:186 → 416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82 → 166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40551174..40595283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878128.1 → XP_059734111.1  retinoic acid receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3

    2. XM_059878129.1 → XP_059734112.1  retinoic acid receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3

    3. XM_005220738.5 → XP_005220795.1  retinoic acid receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_005220795.1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3
      Conserved Domains (2) summary
      cd06937
      Location:186 → 416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82 → 166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    4. XM_059878130.1 → XP_059734113.1  retinoic acid receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3

    5. XM_059878127.1 → XP_059734110.1  retinoic acid receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3

    6. XM_024980268.2 → XP_024836036.1  retinoic acid receptor alpha isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LPI3, F1MWQ3
      Related
      ENSBTAP00070037820.1, ENSBTAT00070063052.1
      Conserved Domains (2) summary
      cd06937
      Location:186 → 416
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82 → 166
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    7. XM_059878131.1 → XP_059734114.1  retinoic acid receptor alpha isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LPI3
      Related
      ENSBTAP00070037764.1, ENSBTAT00070062981.1

    8. XM_024980270.2 → XP_024836038.1  retinoic acid receptor alpha isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LPI3, A0A3Q1M468
      Related
      ENSBTAP00070037738.1, ENSBTAT00070062950.1
      Conserved Domains (2) summary
      cd06937
      Location:183 → 413
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:79 → 163
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    9. XM_005220739.5 → XP_005220796.1  retinoic acid receptor alpha isoform X4

      See identical proteins and their annotated locations for XP_005220796.1

      UniProtKB/TrEMBL
      A0A3Q1LPI3
      Conserved Domains (2) summary
      cd06937
      Location:133 → 363
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:29 → 113
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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