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    HNF1B HNF1 homeobox B [ Bos taurus (domestic cattle) ]

    Gene ID: 503581, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HNF1Bprovided by VGNC
    Official Full Name
    HNF1 homeobox Bprovided by VGNC
    Primary source
    VGNC:VGNC:29890
    See related
    BGD:BT20049; Ensembl:ENSBTAG00000004710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HNF-1b
    Orthologs
    human mouse all
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    Genomic context

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    See HNF1B in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (13973966..14035613, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene synergin gamma Neighboring gene DExD-box helicase 52 Neighboring gene uncharacterized LOC101906072 Neighboring gene uncharacterized LOC104969035 Neighboring gene uncharacterized LOC101906153

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver. Eleswarapu S, et al. J Endocrinol, 2005 Jan. PMID 15642787
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 1-beta
    Names
    hepatocyte nuclear factor 1 beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192855.1 → NP_001179784.1  hepatocyte nuclear factor 1-beta

      See identical proteins and their annotated locations for NP_001179784.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000019
      UniProtKB/TrEMBL
      F1MK03
      Conserved Domains (3) summary
      cd00086
      Location:232 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:314 → 550
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13973966..14035613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005219982.5 → XP_005220039.1  hepatocyte nuclear factor 1-beta isoform X3

      See identical proteins and their annotated locations for XP_005220039.1

      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 524
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    2. XM_005219981.5 → XP_005220038.1  hepatocyte nuclear factor 1-beta isoform X2

      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 525
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    3. XM_005219980.5 → XP_005220037.1  hepatocyte nuclear factor 1-beta isoform X1

      UniProtKB/TrEMBL
      F1MK03
      Related
      ENSBTAP00000006184.6, ENSBTAT00000006184.7
      Conserved Domains (3) summary
      cd00086
      Location:232 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:314 → 551
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 173
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    4. XM_059877790.1 → XP_059733773.1  hepatocyte nuclear factor 1-beta isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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