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    PPFIBP1 PPFIA binding protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 407130, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PPFIBP1provided by VGNC
    Official Full Name
    PPFIA binding protein 1provided by VGNC
    Primary source
    VGNC:VGNC:33193
    See related
    BGD:BT13469; EnsemblRapid:ENSBTAG00070017873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    lip beta1
    Orthologs
    human mouse all
    NEW
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    Try the new Transcript table

    Genomic context

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    See PPFIBP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (82135506..82342805, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene proteasome maturation protein-like Neighboring gene RAB15 effector protein Neighboring gene chromosome 5 C12orf71 homolog Neighboring gene GTP-binding nuclear protein Ran-like Neighboring gene U6 spliceosomal RNA Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene aryl hydrocarbon receptor nuclear translocator like 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Differences between retinal and choroidal microvascular endothelial cells (MVECs) under normal and hypoxic conditions. Brylla E, et al. Exp Eye Res, 2003 Nov. PMID 14550394
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    liprin-beta-1
    Names
    liprin beta1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304798.1 → NP_001291727.1  liprin-beta-1

      See identical proteins and their annotated locations for NP_001291727.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      A0A3Q1LXE1, A0AAA9TTI3
      Related
      ENSBTAP00070023881.1, ENSBTAT00070040324.1
      Conserved Domains (7) summary
      cd09563
      Location:635 → 698
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:709 → 771
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:794 → 865
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:635 → 699
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      cl03075
      Location:223 → 295
      GrpE; nucleotide exchange factor GrpE
      cl23720
      Location:134 → 255
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      82135506..82342805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991420.2 → XP_024847188.1  liprin-beta-1 isoform X10

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (4) summary
      cd09563
      Location:603 → 666
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:677 → 739
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:762 → 833
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:103 → 311
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_024991422.2 → XP_024847190.1  liprin-beta-1 isoform X12

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (5) summary
      cd09563
      Location:613 → 676
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:687 → 749
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:766 → 801
      SAM_superfamily; SAM (Sterile alpha motif )
      cl25574
      Location:102 → 520
      TOP2c; TopoisomeraseII
      cl25732
      Location:103 → 311
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_010805397.4 → XP_010803699.1  liprin-beta-1 isoform X9

      See identical proteins and their annotated locations for XP_010803699.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (8) summary
      cd09563
      Location:613 → 676
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:687 → 749
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:772 → 843
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:613 → 677
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam16001
      Location:216 → 474
      DUF4775; Domain of unknown function (DUF4775)
      cl19219
      Location:229 → 314
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:134 → 255
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. XM_010805396.4 → XP_010803698.1  liprin-beta-1 isoform X6

      See identical proteins and their annotated locations for XP_010803698.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:624 → 688
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      cl19219
      Location:229 → 314
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:134 → 255
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_024991419.2 → XP_024847187.1  liprin-beta-1 isoform X7

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (5) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 321
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25758
      Location:216 → 485
      DUF4775; Domain of unknown function (DUF4775)

    6. XM_024991421.2 → XP_024847189.1  liprin-beta-1 isoform X11

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (5) summary
      cd09563
      Location:635 → 698
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:709 → 771
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cl15755
      Location:788 → 823
      SAM_superfamily; SAM (Sterile alpha motif )
      cl25732
      Location:47 → 321
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:341 → 634
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    7. XM_005206924.5 → XP_005206981.1  liprin-beta-1 isoform X5

      See identical proteins and their annotated locations for XP_005206981.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Related
      ENSBTAP00070023866.1, ENSBTAT00070040309.1
      Conserved Domains (7) summary
      cd09563
      Location:644 → 707
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:718 → 780
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:803 → 874
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:644 → 708
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 494
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    8. XM_005206923.5 → XP_005206980.1  liprin-beta-1 isoform X3

      See identical proteins and their annotated locations for XP_005206980.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:655 → 719
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 494
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    9. XM_010805394.4 → XP_010803696.1  liprin-beta-1 isoform X2

      See identical proteins and their annotated locations for XP_010803696.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:656 → 719
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:730 → 792
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:815 → 886
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:656 → 720
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 476
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    10. XM_010805395.4 → XP_010803697.1  liprin-beta-1 isoform X4

      See identical proteins and their annotated locations for XP_010803697.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:655 → 719
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 505
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    11. XM_015471218.3 → XP_015326704.1  liprin-beta-1 isoform X8

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      smart00454
      Location:666 → 730
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 505
      Rabaptin; Rabaptin
      cl15755
      Location:819 → 854
      SAM_superfamily; SAM (Sterile alpha motif )
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    12. XM_010805392.4 → XP_010803694.1  liprin-beta-1 isoform X1

      See identical proteins and their annotated locations for XP_010803694.1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:666 → 730
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 505
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    13. XM_015471217.3 → XP_015326703.1  liprin-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TTI3
      Conserved Domains (7) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:666 → 730
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam03528
      Location:103 → 505
      Rabaptin; Rabaptin
      cl19219
      Location:203 → 281
      DUF342; Protein of unknown function (DUF342)

    14. XM_059886140.1 → XP_059742123.1  liprin-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TTI3
    Nucleotide Protein Strain
    Heading Accession and Version

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