ACVRL1 activin A receptor like type 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ACVRL1provided by VGNC
Official Full Name: activin A receptor like type 1provided by VGNC
Primary source: VGNC:VGNC:25597
See related: BGD:BT11850; EnsemblRapid:ENSBTAG00070032716
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (27943345..27957129, complement)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that ALK5 and ALK1 play antagonistic roles in TGF-beta-induced podosome formation in aortic endothelial cells.
Title: ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
Title: Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells.

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General gene information

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Markers

MARC_12163-12164:1004710047:3 (e-PCR)
- UniSTS:267350

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of BMP receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: activin receptor type-1-like

Names: activin A receptor type II-like 1; serine/threonine-protein kinase receptor R3

NP_001076948.1

EC 2.7.11.30

XP_010803213.1

EC 2.7.11.30

XP_059742533.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083479.1 → NP_001076948.1 activin receptor type-1-like precursor

See identical proteins and their annotated locations for NP_001076948.1

Status: PROVISIONAL

Source sequence(s)

BC123398

UniProtKB/TrEMBL

A4FUX2, F1MIW7

Related

ENSBTAP00070045040.1, ENSBTAT00070073935.1

Conserved Domains (4) summary

cd14142
Location:196 → 493

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam07714
Location:202 → 489

Pkinase_Tyr; Protein tyrosine kinase

pfam08515
Location:173 → 200

TGF_beta_GS; Transforming growth factor beta type I GS-motif

cl10471
Location:33 → 103

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

Range

27943345..27957129 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010804911.4 → XP_010803213.1 activin receptor type-1-like isoform X1

See identical proteins and their annotated locations for XP_010803213.1

UniProtKB/TrEMBL

F1MIW7

Conserved Domains (3) summary

cd14142
Location:196 → 493

STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1

pfam08515
Location:173 → 200

TGF_beta_GS; Transforming growth factor beta type I GS-motif

cl10471
Location:34 → 96

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_059886550.1 → XP_059742533.1 activin receptor type-1-like isoform X1

UniProtKB/TrEMBL

F1MIW7