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    ARHGEF3 Rho guanine nucleotide exchange factor 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 782247, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ARHGEF3provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 3provided by VGNC
    Primary source
    VGNC:VGNC:26115
    See related
    BGD:BT21139; Ensembl:ENSBTAG00000014091
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF3 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (44017412..44330994)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene HESX homeobox 1 Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC112443464 Neighboring gene transcription activation suppressor Neighboring gene coiled-coil domain containing 66 Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene microRNA mir-2371

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 3
    Names
    Rho guanine nucleotide exchange factor (GEF) 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44017412..44330994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003587632.6 → XP_003587680.1  rho guanine nucleotide exchange factor 3 isoform X1

      See identical proteins and their annotated locations for XP_003587680.1

      UniProtKB/TrEMBL
      A0AAA9RTD0
      Related
      ENSBTAP00000076176.1, ENSBTAT00000114307.1
      Conserved Domains (2) summary
      smart00325
      Location:152 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd10572
      Location:342 → 474
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

    2. XM_059880073.1 → XP_059736056.1  rho guanine nucleotide exchange factor 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RTD0

    3. XM_059880075.1 → XP_059736058.1  rho guanine nucleotide exchange factor 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RTD0

    4. XM_059880074.1 → XP_059736057.1  rho guanine nucleotide exchange factor 3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RTD0
      Related
      ENSBTAP00000096450.1, ENSBTAT00000108118.1

    5. XM_059880077.1 → XP_059736060.1  rho guanine nucleotide exchange factor 3 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MQJ3
      Related
      ENSBTAP00000072028.2, ENSBTAT00000074958.2

    6. XM_005222973.5 → XP_005223030.1  rho guanine nucleotide exchange factor 3 isoform X3

      See identical proteins and their annotated locations for XP_005223030.1

      UniProtKB/TrEMBL
      A0A3Q1MMQ5, A0A3Q1MQJ3
      Related
      ENSBTAP00000072461.1, ENSBTAT00000072941.2
      Conserved Domains (2) summary
      smart00325
      Location:132 → 308
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd10572
      Location:322 → 454
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

    7. XM_002697002.3 → XP_002697048.1  rho guanine nucleotide exchange factor 3 isoform X5

      See identical proteins and their annotated locations for XP_002697048.1

      UniProtKB/TrEMBL
      A0A3Q1MQJ3, F1MNV2
      Related
      ENSBTAP00000018734.5, ENSBTAT00000018734.7
      Conserved Domains (2) summary
      smart00325
      Location:126 → 302
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd10572
      Location:316 → 448
      PH_RhoGEF3_XPLN; Rho guanine nucleotide exchange factor 3 Pleckstrin homology (PH) domain

    8. XM_059880076.1 → XP_059736059.1  rho guanine nucleotide exchange factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MQJ3
      Related
      ENSBTAP00000067512.2, ENSBTAT00000077427.2

    9. XM_059880078.1 → XP_059736061.1  rho guanine nucleotide exchange factor 3 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MQJ3
    Nucleotide Protein Strain
    Heading Accession and Version

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