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    PLEKHM2 pleckstrin homology and RUN domain containing M2 [ Bos taurus (domestic cattle) ]

    Gene ID: 515552, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PLEKHM2provided by VGNC
    Official Full Name
    pleckstrin homology and RUN domain containing M2provided by VGNC
    Primary source
    VGNC:VGNC:33024
    See related
    EnsemblRapid:ENSBTAG00070021664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See PLEKHM2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (51825824..51865781, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112441770 Neighboring gene solute carrier family 25 member 34 Neighboring gene transmembrane protein 82 Neighboring gene U6 spliceosomal RNA Neighboring gene DNA damage inducible 1 homolog 2 Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lysosome localization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family M member 2
    Names
    pleckstrin homology domain containing, family M (with RUN domain) member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192416.2 → NP_001179345.1  pleckstrin homology domain-containing family M member 2

      Status: VALIDATED

      Source sequence(s)
      CB438536, DN538966, NKLS02000016
      UniProtKB/TrEMBL
      F1MRW6
      Conserved Domains (3) summary
      smart00593
      Location:93 → 156
      RUN; domain involved in Ras-like GTPase signaling
      cd13309
      Location:780 → 882
      PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
      pfam00169
      Location:779 → 880
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51825824..51865781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059875380.1 → XP_059731363.1  pleckstrin homology domain-containing family M member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LMH7, A0A3Q1MLR3
      Related
      ENSBTAP00070029160.1, ENSBTAT00070048865.1

    2. XM_059875379.1 → XP_059731362.1  pleckstrin homology domain-containing family M member 2 isoform X1

      UniProtKB/TrEMBL
      F1MRW6
      Related
      ENSBTAP00070029138.1, ENSBTAT00070048813.1

    3. XM_059875381.1 → XP_059731364.1  pleckstrin homology domain-containing family M member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LMH7, A0A3Q1MLR3

    4. XM_059875382.1 → XP_059731365.1  pleckstrin homology domain-containing family M member 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MLR3
    Nucleotide Protein Strain
    Heading Accession and Version

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