U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IARS1 isoleucyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 509885, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    IARS1provided by VGNC
    Official Full Name
    isoleucyl-tRNA synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:30018
    See related
    BGD:BT24147; Ensembl:ENSBTAG00000000974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IARS
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See IARS1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (83837391..83918584, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis-associated protein 31A3-like Neighboring gene zinc finger protein 484 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. IARS mutation causes prenatal death in Japanese Black cattle. Hirano T, et al. Anim Sci J, 2016 Sep. PMID 27229878
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Its mutation causes prenatal death in Japanese Black cattle
      Title: IARS mutation causes prenatal death in Japanese Black cattle.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    isoleucine tRNA synthetase
    NP_001094539.1
    XP_005210483.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101069.2 → NP_001094539.1  isoleucine--tRNA ligase, cytoplasmic

      Status: PROVISIONAL

      Source sequence(s)
      BC151484
      UniProtKB/TrEMBL
      A0AAA9TK25, A7MBC5
      Related
      ENSBTAP00000001290.4, ENSBTAT00000001290.6
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 → 1070
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      83837391..83918584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005210426.5 → XP_005210483.1  isoleucine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0AAA9TK25, A7MBC5
      Conserved Domains (3) summary
      cd07961
      Location:640 → 833
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 → 640
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 → 1070
      PLN02882; aminoacyl-tRNA ligase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.