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    DAB2 DAB adaptor protein 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 509221, updated on 1-Jan-2025

    Summary

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    Official Symbol
    DAB2provided by VGNC
    Official Full Name
    DAB adaptor protein 2provided by VGNC
    Primary source
    VGNC:VGNC:27865
    See related
    BGD:BT19326; Ensembl:ENSBTAG00000016152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DAB2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (35004200..35064451)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443045 Neighboring gene uncharacterized LOC112443037 Neighboring gene complement C9 Neighboring gene FYN binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. Lau A, et al. Exp Biol Med (Maywood), 2014 Jan. PMID 24186266
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disabled homolog 2
    Names
    DAB2, clathrin adaptor protein
    disabled homolog 2, mitogen-responsive phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193246.2 → NP_001180175.1  disabled homolog 2

      See identical proteins and their annotated locations for NP_001180175.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000020
      UniProtKB/TrEMBL
      F1N371
      Related
      ENSBTAP00000021501.5, ENSBTAT00000021501.7
      Conserved Domains (2) summary
      cd01215
      Location:36 → 171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      cl26464
      Location:394 → 611
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35004200..35064451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878690.1 → XP_059734673.1  disabled homolog 2 isoform X1

      UniProtKB/TrEMBL
      F1N371

    2. XM_005221592.3 → XP_005221649.1  disabled homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005221649.1

      UniProtKB/TrEMBL
      F1N371
      Conserved Domains (2) summary
      cd01215
      Location:36 → 171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      cl26464
      Location:394 → 611
      Atrophin-1; Atrophin-1 family

    3. XM_015459082.3 → XP_015314568.1  disabled homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LKF9, A0A3Q1MXS6
      Related
      ENSBTAP00000060061.1, ENSBTAT00000078306.2
      Conserved Domains (2) summary
      cd01215
      Location:36 → 171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      cl26464
      Location:221 → 393
      Atrophin-1; Atrophin-1 family

    4. XM_010816799.3 → XP_010815101.1  disabled homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LSX5
      Related
      ENSBTAP00000060131.1, ENSBTAT00000079720.2
      Conserved Domains (2) summary
      cd01215
      Location:36 → 171
      PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
      cl26464
      Location:373 → 590
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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