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    MC2R melanocortin 2 receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 281299, updated on 29-Jan-2025

    Summary

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    Official Symbol
    MC2Rprovided by VGNC
    Official Full Name
    melanocortin 2 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:31293
    See related
    BGD:BT10871; Ensembl:ENSBTAG00000011038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MC2R in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (43564576..43583046, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene RNA guanine-7 methyltransferase Neighboring gene melanocortin 5 receptor Neighboring gene uncharacterized LOC101902809 Neighboring gene glutamine synthetase pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular genetics of the ACTH and melanocyte-stimulating hormone receptors. Cone RD, et al. Trends Endocrinol Metab, 1993 Sep. PMID 18407163
    2. cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor. Raikhinstein M, et al. Biochim Biophys Acta, 1994 Feb 17. PMID 8305507
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables corticotropin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adrenocorticotropic hormone receptor
    Names
    ACTH receptor
    ACTH-R
    MC2-R
    adrenocorticotropin receptor
    melanocortin receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174109.2 → NP_776534.1  adrenocorticotropic hormone receptor

      See identical proteins and their annotated locations for NP_776534.1

      Status: PROVISIONAL

      Source sequence(s)
      X74501
      UniProtKB/Swiss-Prot
      P34974
      Related
      ENSBTAP00070031852.1, ENSBTAT00070052993.1
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 276
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 290
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43564576..43583046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34974.1 GenPept UniProtKB/Swiss-Prot:P34974

    Gene LinkOut

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