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    CA4 carbonic anhydrase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 280741, updated on 29-Jan-2025

    Summary

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    Official Symbol
    CA4provided by VGNC
    Official Full Name
    carbonic anhydrase 4provided by VGNC
    Primary source
    VGNC:VGNC:26654
    See related
    BGD:BT11512; Ensembl:ENSBTAG00000017969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CA4 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (12804065..12811833, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 32 Neighboring gene V-type proton ATPase subunit G 3-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343008 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene myosin XIX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbonic anhydrase 4
    Names
    CA-IV
    carbonate dehydratase IV
    carbonic anhydrase IV
    NP_776322.1
    XP_005220030.1
    XP_024835300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173897.1 → NP_776322.1  carbonic anhydrase 4 precursor

      See identical proteins and their annotated locations for NP_776322.1

      Status: PROVISIONAL

      Source sequence(s)
      U58870
      UniProtKB/Swiss-Prot
      A5PKL8, Q95323
      UniProtKB/TrEMBL
      A0A3Q1LST6
      Related
      ENSBTAP00070045563.1, ENSBTAT00070074826.1
      Conserved Domains (1) summary
      cd03117
      Location:49 → 283
      alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      12804065..12811833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005219973.3 → XP_005220030.1  carbonic anhydrase 4 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LST6, A0AAA9RTE0
      Related
      ENSBTAP00070045540.1, ENSBTAT00070074796.1
      Conserved Domains (1) summary
      cd03117
      Location:35 → 269
      alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. XM_024979532.2 → XP_024835300.1  carbonic anhydrase 4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LST6
      Conserved Domains (1) summary
      cd03117
      Location:89 → 323
      alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95323.1 GenPept UniProtKB/Swiss-Prot:Q95323

    Gene LinkOut

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