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    PTPN2 protein tyrosine phosphatase non-receptor type 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 540888, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PTPN2provided by VGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 2provided by VGNC
    Primary source
    VGNC:VGNC:33534
    See related
    BGD:BT21463; Ensembl:ENSBTAG00000010563
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTPN2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (43078849..43165170, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene spire type actin nucleation factor 1 Neighboring gene S-methyl-5'-thioadenosine phosphorylase pseudogene Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene centrosomal protein 76 Neighboring gene prefoldin subunit 4-like Neighboring gene proteasome assembly chaperone 2 Neighboring gene uncharacterized LOC132343780 Neighboring gene uncharacterized LOC132343781 Neighboring gene SEH1 like nucleoporin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC127015

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 2
    NP_001030508.1
    XP_005224318.1
    XP_005224320.1
    XP_010817234.1
    XP_059736957.1
    XP_059736958.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035431.2 → NP_001030508.1  tyrosine-protein phosphatase non-receptor type 2

      See identical proteins and their annotated locations for NP_001030508.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102127
      UniProtKB/TrEMBL
      A0AAA9T071, Q3T151
      Related
      ENSBTAP00070031413.1, ENSBTAT00070052357.1
      Conserved Domains (2) summary
      smart00194
      Location:5 → 275
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:45 → 275
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43078849..43165170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880975.1 → XP_059736958.1  tyrosine-protein phosphatase non-receptor type 2 isoform X4

      UniProtKB/TrEMBL
      A0AAA9T071, A5D982

    2. XM_059880974.1 → XP_059736957.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9S252, A0AAA9T071
      Related
      ENSBTAP00070031407.1, ENSBTAT00070052340.1

    3. XM_005224263.5 → XP_005224320.1  tyrosine-protein phosphatase non-receptor type 2 isoform X3

      See identical proteins and their annotated locations for XP_005224320.1

      UniProtKB/TrEMBL
      A0A3Q1MPM2, A0AAA9T071
      Conserved Domains (1) summary
      smart00194
      Location:5 → 275
      PTPc; Protein tyrosine phosphatase, catalytic domain

    4. XM_010818932.4 → XP_010817234.1  tyrosine-protein phosphatase non-receptor type 2 isoform X3

      See identical proteins and their annotated locations for XP_010817234.1

      UniProtKB/TrEMBL
      A0A3Q1MPM2, A0AAA9T071
      Related
      ENSBTAP00070031386.1, ENSBTAT00070052289.1
      Conserved Domains (1) summary
      smart00194
      Location:5 → 275
      PTPc; Protein tyrosine phosphatase, catalytic domain

    5. XM_005224261.5 → XP_005224318.1  tyrosine-protein phosphatase non-receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_005224318.1

      UniProtKB/TrEMBL
      A0AAA9T071, A0AAA9TAZ9
      Related
      ENSBTAP00070031401.1, ENSBTAT00070052327.1
      Conserved Domains (1) summary
      smart00194
      Location:5 → 275
      PTPc; Protein tyrosine phosphatase, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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