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    ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 513700, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ITIH4provided by VGNC
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain 4provided by VGNC
    Primary source
    VGNC:VGNC:30336
    See related
    BGD:BT23730; EnsemblRapid:ENSBTAG00070031545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ITIH4 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (48059589..48074580)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene STIM activating enhancer Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection. Piñeiro M, et al. Infect Immun, 2004 Jul. PMID 15213118, Free PMC Article
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H4
    Names
    ITI heavy chain H4
    ITI-HC4
    inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
    inter-alpha-inhibitor heavy chain 4
    inter-alpha-trypsin inhibitor heavy chain family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015590.3 → NP_001015590.2  inter-alpha-trypsin inhibitor heavy chain H4 precursor

      See identical proteins and their annotated locations for NP_001015590.2

      Status: PROVISIONAL

      Source sequence(s)
      BC102561
      UniProtKB/Swiss-Prot
      Q3T052
      UniProtKB/TrEMBL
      F1MMD7
      Related
      ENSBTAP00070043688.1, ENSBTAT00070071571.1
      Conserved Domains (4) summary
      smart00609
      Location:32 → 149
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:272 → 453
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:41 → 593
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:752 → 914
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      48059589..48074580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024982638.2 → XP_024838406.1  inter-alpha-trypsin inhibitor heavy chain H4 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MA31, F1MMD7
      Related
      ENSBTAP00070043721.1, ENSBTAT00070071623.1
      Conserved Domains (4) summary
      smart00609
      Location:32 → 149
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:272 → 453
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:733 → 897
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      pfam09422
      Location:659 → 716
      WTX; WTX protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T052.1 GenPept UniProtKB/Swiss-Prot:Q3T052

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