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    TYRO3 TYRO3 protein tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 788224, updated on 29-Jan-2025

    Summary

    Official Symbol
    TYRO3provided by VGNC
    Official Full Name
    TYRO3 protein tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:36551
    See related
    BGD:BT17751; Ensembl:ENSBTAG00000001694
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TYRO3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (36960778..36979417)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene synaptosomal-associated protein 23-like Neighboring gene U6 spliceosomal RNA Neighboring gene MAX dimerization protein MGA

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase receptor TYRO3
    NP_001178157.1
    XP_005211677.1
    XP_005211678.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191228.1NP_001178157.1  tyrosine-protein kinase receptor TYRO3 precursor

      See identical proteins and their annotated locations for NP_001178157.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      A0A3Q1LRR9
      Related
      ENSBTAP00070036066.1, ENSBTAT00070060665.1
      Conserved Domains (7) summary
      cd05749
      Location:140219
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00408
      Location:55120
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:48134
      IG_like; Immunoglobulin like
      cd00063
      Location:224316
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:507790
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:323405
      fn3; Fibronectin type III domain
      pfam07714
      Location:517785
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36960778..36979417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211620.4XP_005211677.1  tyrosine-protein kinase receptor TYRO3 isoform X1

      Related
      ENSBTAP00070036078.1, ENSBTAT00070060680.1
      Conserved Domains (7) summary
      cd05749
      Location:102181
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00408
      Location:1782
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:1096
      IG_like; Immunoglobulin like
      cd00063
      Location:186278
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:469752
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:285367
      fn3; Fibronectin type III domain
      pfam07714
      Location:479747
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_005211621.5XP_005211678.1  tyrosine-protein kinase receptor TYRO3 isoform X2

      See identical proteins and their annotated locations for XP_005211678.1

      Conserved Domains (7) summary
      cd05749
      Location:96175
      Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
      smart00408
      Location:1176
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:490
      IG_like; Immunoglobulin like
      cd00063
      Location:180272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:463746
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:279361
      fn3; Fibronectin type III domain
      pfam07714
      Location:473741
      Pkinase_Tyr; Protein tyrosine kinase