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    NACA nascent polypeptide associated complex subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 513312, updated on 29-Jan-2025

    Summary

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    Gene symbol
    NACA
    Gene description
    nascent polypeptide associated complex subunit alpha
    See related
    BGD:BT18658; Ensembl:ENSBTAG00000010701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NACA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56732630..56743638)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene DNA primase subunit 1 Neighboring gene uncharacterized LOC132345299 Neighboring gene cytohesin-2-like Neighboring gene prostaglandin E synthase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A protein complex required for signal-sequence-specific sorting and translocation. Wiedmann B, et al. Nature, 1994 Aug 11. PMID 8047162
    2. The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. Beatrix B, et al. J Biol Chem, 2000 Dec 1. PMID 10982809
    3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nascent polypeptide-associated complex subunit alpha
    Names
    NAC-alpha
    alpha-NAC
    nascent polypeptide-associated complex alpha subunit
    nascent-polypeptide-associated complex alpha polypeptide
    NP_001014916.1
    XP_005206630.1
    XP_005206631.1
    XP_005206632.1
    XP_005206634.1
    XP_005206635.1
    XP_024847421.1
    XP_059742317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014916.4 → NP_001014916.1  nascent polypeptide-associated complex subunit alpha

      See identical proteins and their annotated locations for NP_001014916.1

      Status: VALIDATED

      Source sequence(s)
      BC102357
      UniProtKB/Swiss-Prot
      Q3T0K5, Q5E9A1
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56732630..56743638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886334.1 → XP_059742317.1  nascent polypeptide-associated complex subunit alpha isoform X1

    2. XM_024991653.2 → XP_024847421.1  nascent polypeptide-associated complex subunit alpha isoform X2

      UniProtKB/Swiss-Prot
      Q3T0K5, Q5E9A1
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    3. XM_005206574.5 → XP_005206631.1  nascent polypeptide-associated complex subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_005206631.1

      Conserved Domains (3) summary
      COG1308
      Location:1615 → 1756
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14415
      Location:1710 → 1755
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:1616 → 1669
      NAC; NAC domain

    4. XM_005206575.5 → XP_005206632.1  nascent polypeptide-associated complex subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_005206632.1

      Conserved Domains (3) summary
      COG1308
      Location:1615 → 1756
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14415
      Location:1710 → 1755
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:1616 → 1669
      NAC; NAC domain

    5. XM_005206578.2 → XP_005206635.1  nascent polypeptide-associated complex subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_005206635.1

      UniProtKB/Swiss-Prot
      Q3T0K5, Q5E9A1
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    6. XM_005206573.5 → XP_005206630.1  nascent polypeptide-associated complex subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_005206630.1

      Conserved Domains (3) summary
      COG1308
      Location:1615 → 1756
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14415
      Location:1710 → 1755
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:1616 → 1669
      NAC; NAC domain

    7. XM_005206577.4 → XP_005206634.1  nascent polypeptide-associated complex subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_005206634.1

      UniProtKB/Swiss-Prot
      Q3T0K5, Q5E9A1
      Related
      ENSBTAP00070015827.1, ENSBTAT00070026579.1
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9A1.1 GenPept UniProtKB/Swiss-Prot:Q5E9A1

    Gene LinkOut

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