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    DLAT dihydrolipoamide S-acetyltransferase [ Bos taurus (domestic cattle) ]

    Gene ID: 512723, updated on 30-Jan-2025

    Summary

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    Official Symbol
    DLATprovided by VGNC
    Official Full Name
    dihydrolipoamide S-acetyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:109392
    See related
    EnsemblRapid:ENSBTAG00070033594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PDCE2; PDC-E2
    Orthologs
    human mouse all
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    Genomic context

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    See DLAT in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (22340056..22374925)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene chromosome 15 C11orf52 homolog Neighboring gene DIX domain containing 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene PIH1 domain containing 2 Neighboring gene NKAP domain containing 1 Neighboring gene translocase of inner mitochondrial membrane 8 homolog B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2-oxoglutarate dehydrogenase (E1) component of the mammalian 2-oxoglutarate dehydrogenase multienzyme complex. Rice JE, et al. EMBO J, 1992 Sep. PMID 1505515, Free PMC Article
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    Names
    Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
    Pyruvate dehydrogenase complex component E2
    dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
    NP_001192659.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205730.2 → NP_001192659.2  dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

      See identical proteins and their annotated locations for NP_001192659.2

      Status: VALIDATED

      Source sequence(s)
      AW653048, DT900308, DV808203, DV912618, DY133435, EE252483, EV678857, EV678914
      UniProtKB/Swiss-Prot
      F1N690, P11180, V6F7T1
      UniProtKB/TrEMBL
      A0AAA9S734
      Related
      ENSBTAP00070046528.1, ENSBTAT00070076436.1
      Conserved Domains (4) summary
      cd06849
      Location:219 → 293
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:221 → 647
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:436 → 647
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
      pfam02817
      Location:356 → 389
      E3_binding; e3 binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22340056..22374925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11180.2 GenPept UniProtKB/Swiss-Prot:P11180

    Gene LinkOut

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