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    KRIT1 KRIT1 ankyrin repeat containing [ Bos taurus (domestic cattle) ]

    Gene ID: 407996, updated on 27-Dec-2024

    Summary

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    Official Symbol
    KRIT1provided by VGNC
    Official Full Name
    KRIT1 ankyrin repeat containingprovided by VGNC
    Primary source
    VGNC:VGNC:30714
    See related
    BGD:BT22184; Ensembl:ENSBTAG00000002750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CCM1
    Orthologs
    human mouse all
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    Genomic context

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    See KRIT1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (9528491..9567845, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene uncharacterized LOC112446355 Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene small ribosomal subunit protein uS8-like Neighboring gene microRNA mir-584-5 Neighboring gene transmembrane BAX inhibitor motif containing 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. Glading A, et al. J Cell Biol, 2007 Oct 22. PMID 17954608, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    krev interaction trapped protein 1
    Names
    cerebral cavernous malformations 1 protein homolog
    krev interaction trapped 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001166.1 → NP_001001166.1  krev interaction trapped protein 1

      See identical proteins and their annotated locations for NP_001001166.1

      Status: PROVISIONAL

      Source sequence(s)
      AY391713
      UniProtKB/Swiss-Prot
      Q6TNJ1
      UniProtKB/TrEMBL
      A0AAA9T8A8
      Conserved Domains (7) summary
      smart00295
      Location:421 → 640
      B41; Band 4.1 homologues
      cd00204
      Location:291 → 411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636 → 735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      pfam00373
      Location:521 → 640
      FERM_M; FERM central domain
      pfam12796
      Location:292 → 386
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30 → 198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
      sd00045
      Location:291 → 318
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9528491..9567845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010803972.4 → XP_010802274.1  krev interaction trapped protein 1 isoform X2

      See identical proteins and their annotated locations for XP_010802274.1

      UniProtKB/TrEMBL
      A0AAA9T8A8
      Conserved Domains (5) summary
      smart00295
      Location:328 → 547
      B41; Band 4.1 homologues
      cd00204
      Location:198 → 318
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:543 → 642
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:198 → 225
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:1 → 105
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    2. XM_015467969.3 → XP_015323455.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T8A8, A7Z069
      Conserved Domains (5) summary
      smart00295
      Location:421 → 640
      B41; Band 4.1 homologues
      cd13197
      Location:636 → 735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291 → 318
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:292 → 386
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30 → 198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    3. XM_005205118.5 → XP_005205175.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005205175.1

      UniProtKB/TrEMBL
      A0AAA9T8A8, A7Z069
      Conserved Domains (5) summary
      smart00295
      Location:421 → 640
      B41; Band 4.1 homologues
      cd13197
      Location:636 → 735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291 → 318
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:292 → 386
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30 → 198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    4. XM_005205119.5 → XP_005205176.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005205176.1

      UniProtKB/TrEMBL
      A0AAA9T8A8, A7Z069
      Related
      ENSBTAP00000003566.4, ENSBTAT00000003566.6
      Conserved Domains (5) summary
      smart00295
      Location:421 → 640
      B41; Band 4.1 homologues
      cd13197
      Location:636 → 735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291 → 318
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:292 → 386
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30 → 198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    5. XM_059885429.1 → XP_059741412.1  krev interaction trapped protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TNJ1.1 GenPept UniProtKB/Swiss-Prot:Q6TNJ1

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