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    ATP8A1 ATPase phospholipid transporting 8A1 [ Bos taurus (domestic cattle) ]

    Gene ID: 317692, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ATP8A1provided by VGNC
    Official Full Name
    ATPase phospholipid transporting 8A1provided by VGNC
    Primary source
    VGNC:VGNC:26329
    See related
    BGD:BT10514; Ensembl:ENSBTAG00000011156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ATP8A1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (61240030..61478165, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447075 Neighboring gene shisa family member 3 Neighboring gene microRNA mir-2285cs Neighboring gene uncharacterized LOC132345508 Neighboring gene glutaredoxin and cysteine rich domain containing 1 Neighboring gene HIV Tat-specific factor 1 homolog Neighboring gene uncharacterized LOC112447156

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation. Mikkelsen SA, et al. J Biol Chem, 2019 Apr 12. PMID 30760526, Free PMC Article
    2. A subfamily of P-type ATPases with aminophospholipid transporting activity. Tang X, et al. Science, 1996 Jun 7. PMID 8633245
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation.
      Title: Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IA
    Names
    ATPase class I type 8A member 1
    chromaffin granule ATPase II
    NP_777263.1
    XP_024848805.1
    XP_024848806.1
    XP_024848807.1
    XP_024848808.1
    XP_024848809.1
    XP_024848810.1
    XP_024848814.1
    XP_059743336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174838.2 → NP_777263.1  probable phospholipid-transporting ATPase IA

      See identical proteins and their annotated locations for NP_777263.1

      Status: PROVISIONAL

      Source sequence(s)
      U51100
      UniProtKB/Swiss-Prot
      Q29449
      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Related
      ENSBTAP00070001999.1, ENSBTAT00070003440.1
      Conserved Domains (6) summary
      TIGR01652
      Location:49 → 1071
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:106 → 191
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:471 → 566
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:38 → 100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:812 → 1064
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:781 → 810
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61240030..61478165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993042.2 → XP_024848810.1  probable phospholipid-transporting ATPase IA isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1071
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    2. XM_024993040.2 → XP_024848808.1  probable phospholipid-transporting ATPase IA isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LQ26, A0A3Q1MQL3
      Related
      ENSBTAP00070001995.1, ENSBTAT00070003432.1
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1086
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    3. XM_024993038.2 → XP_024848806.1  probable phospholipid-transporting ATPase IA isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1096
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    4. XM_024993041.2 → XP_024848809.1  probable phospholipid-transporting ATPase IA isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1081
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    5. XM_024993039.2 → XP_024848807.1  probable phospholipid-transporting ATPase IA isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1086
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    6. XM_024993037.2 → XP_024848805.1  probable phospholipid-transporting ATPase IA isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1096
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    7. XM_059887353.1 → XP_059743336.1  probable phospholipid-transporting ATPase IA isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LQ26

    8. XM_024993046.2 → XP_024848814.1  probable phospholipid-transporting ATPase IA isoform X8

      UniProtKB/TrEMBL
      A0A3Q1LQ26
      Conserved Domains (1) summary
      cl26237
      Location:1 → 917
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29449.2 GenPept UniProtKB/Swiss-Prot:Q29449

    Gene LinkOut

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