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    SETD2 SET domain containing 2 [ Gallus gallus (chicken) ]

    Gene ID: 420404, updated on 3-Dec-2024

    Summary

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    Symbol
    SETD2provided by CGNC
    Full Name
    SET domain containing 2provided by CGNC
    Primary source
    CGNC:4103
    See related
    Ensembl:ENSGALG00010025723
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SETD2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (3906183..3959895, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (3908587..3962351, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene neurobeachin like 2 Neighboring gene tumor necrosis factor receptor superfamily, member 14 Neighboring gene chicken D-serine dehydratase Neighboring gene uncharacterized LOC121110138 Neighboring gene kinesin family member 9 Neighboring gene kelch like family member 18 Neighboring gene uncharacterized LOC124417717

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development. Roffers-Agarwal J, et al. Genesis, 2021 Oct. PMID 34498354
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development.
      Title: The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SETD2
    XP_015136611.2
    XP_040522127.1
    XP_040522128.1
    XP_046768119.1
    XP_046768120.1
    XP_046789463.1
    XP_046789465.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      3906183..3959895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015281125.4 → XP_015136611.2  histone-lysine N-methyltransferase SETD2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A429, A0A8V1A910
      Related
      ENSGALP00010038795.1, ENSGALT00010062777.1
      Conserved Domains (4) summary
      smart00570
      Location:1497 → 1551
      AWS; associated with SET domains
      PRK10263
      Location:2168 → 2365
      PRK10263; DNA translocase FtsK; Provisional
      cd00201
      Location:2387 → 2417
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd19172
      Location:1551 → 1692
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins

    2. XM_046933507.1 → XP_046789463.1  histone-lysine N-methyltransferase SETD2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A429

    3. XM_046933509.1 → XP_046789465.1  histone-lysine N-methyltransferase SETD2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A429

    RNA

    1. XR_005858054.2 RNA Sequence

    2. XR_005858053.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3908587..3962351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040666194.2 → XP_040522128.1  histone-lysine N-methyltransferase SETD2 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A429
      Conserved Domains (4) summary
      smart00570
      Location:1497 → 1551
      AWS; associated with SET domains
      PRK10263
      Location:2125 → 2322
      PRK10263; DNA translocase FtsK; Provisional
      cd00201
      Location:2344 → 2374
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd19172
      Location:1551 → 1692
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins

    2. XM_040666193.2 → XP_040522127.1  histone-lysine N-methyltransferase SETD2 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A429
      Conserved Domains (4) summary
      smart00570
      Location:1497 → 1551
      AWS; associated with SET domains
      PRK10263
      Location:2168 → 2365
      PRK10263; DNA translocase FtsK; Provisional
      cd00201
      Location:2387 → 2417
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd19172
      Location:1551 → 1692
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins

    3. XM_046912163.1 → XP_046768119.1  histone-lysine N-methyltransferase SETD2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A429

    4. XM_046912164.1 → XP_046768120.1  histone-lysine N-methyltransferase SETD2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A429

    RNA

    1. XR_005847614.2 RNA Sequence

    2. XR_005847613.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials