STAT1 signal transducer and activator of transcription 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: STAT1provided by CGNC
Official Full Name: signal transducer and activator of transcription 1provided by CGNC
Primary source: CGNC:52118
See related: Ensembl:ENSGALG00010013934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (7514315..7534828, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (7438264..7458794, complement)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Avian coronavirus infectious bronchitis virus Beaudette strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication.
Title: Avian coronavirus infectious bronchitis virus Beaudette strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication.
the role of STAT1 in NLRC5 regulation following infection with Salmonella pullorum.STAT1 plays crucial role in NLRC5 promoter activity.
Title: Expression patterns of NLRC5 and key genes in the STAT1 pathway following infection with Salmonella pullorum.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 1-alpha/beta

Names: signal transducer and activator of transcription 1, 91kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012914.2 → NP_001012932.1 signal transducer and activator of transcription 1-alpha/beta

See identical proteins and their annotated locations for NP_001012932.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000236

UniProtKB/TrEMBL

A0A8V0YP10, Q5ZJK3

Related

ENSGALP00010019718.1, ENSGALT00010033422.1

Conserved Domains (5) summary

cd10372
Location:561 → 709

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:141 → 317

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:319 → 570

STAT_bind; STAT protein, DNA binding domain

pfam12162
Location:717 → 741

STAT1_TAZ2bind; STAT1 TAZ2 binding domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

7514315..7534828 complement

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GenBank, FASTA, Sequence Viewer (Graphics)