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    SCN5A sodium voltage-gated channel alpha subunit 5 [ Gallus gallus (chicken) ]

    Gene ID: 395947, updated on 3-Dec-2024

    Summary

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    Symbol
    SCN5Aprovided by CGNC
    Full Name
    sodium voltage-gated channel alpha subunit 5provided by CGNC
    Primary source
    CGNC:49568
    See related
    Ensembl:ENSGALG00010027095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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    Genomic context

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    See SCN5A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (5433099..5638472)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (5436015..5641603)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene voltage-gated sodium channel SNS Neighboring gene activin A receptor type 2B Neighboring gene exo/endonuclease G Neighboring gene microRNA 6600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons. Friedel RH, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356508, Free PMC Article
    2. Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity. Zakon HH, et al. Mol Biol Evol, 2011 Apr. PMID 21148285, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium channel protein type 5 subunit alpha
    Names
    oltage-gated sodium channel type V alpha
    sodium channel, voltage-gated, type V, alpha subunit
    voltage-dependent sodium channel SCN10A
    voltage-gated sodium channel H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318446.3 → NP_001305375.3  sodium channel protein type 5 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000035
      UniProtKB/TrEMBL
      A0A8V1A735
      Related
      ENSGALP00010039935.1, ENSGALT00010065669.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      5433099..5638472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040675933.2 → XP_040531867.1  sodium channel protein type 5 subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V1A735
      Related
      ENSGALP00010039940.1, ENSGALT00010065674.1
      Conserved Domains (2) summary
      PLN03223
      Location:1624 → 1803
      PLN03223; Polycystin cation channel protein; Provisional
      cd13433
      Location:1487 → 1539
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

    2. XM_040675923.2 → XP_040531857.1  sodium channel protein type 5 subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V1A735
      Conserved Domains (2) summary
      PLN03223
      Location:1624 → 1803
      PLN03223; Polycystin cation channel protein; Provisional
      cd13433
      Location:1487 → 1539
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

    3. XM_015281250.4 → XP_015136736.3  sodium channel protein type 5 subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8V1A735
      Conserved Domains (2) summary
      PLN03223
      Location:1623 → 1802
      PLN03223; Polycystin cation channel protein; Provisional
      cd13433
      Location:1486 → 1538
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

    4. XM_015281251.4 → XP_015136737.3  sodium channel protein type 5 subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A8V1A9N2
      Related
      ENSGALP00010039942.1, ENSGALT00010065676.1
      Conserved Domains (2) summary
      PLN03223
      Location:1575 → 1754
      PLN03223; Polycystin cation channel protein; Provisional
      cd13433
      Location:1438 → 1490
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

    5. XM_015281252.4 → XP_015136738.3  sodium channel protein type 5 subunit alpha isoform X5

      UniProtKB/TrEMBL
      A0A8V1A735
      Conserved Domains (2) summary
      PLN03223
      Location:1490 → 1669
      PLN03223; Polycystin cation channel protein; Provisional
      cd13433
      Location:1353 → 1405
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      5436015..5641603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910387.1 → XP_046766343.1  sodium channel protein type 5 subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8V1A735

    2. XM_046910386.1 → XP_046766342.1  sodium channel protein type 5 subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8V1A735

    3. XM_046910388.1 → XP_046766344.1  sodium channel protein type 5 subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8V1A735

    4. XM_046910389.1 → XP_046766345.1  sodium channel protein type 5 subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A8V1A9N2

    5. XM_046910390.1 → XP_046766346.1  sodium channel protein type 5 subunit alpha isoform X5

      UniProtKB/TrEMBL
      A0A8V1A735
    Nucleotide Protein
    Heading Accession and Version

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