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    FANCL Fanconi anemia complementation group L [ Gallus gallus (chicken) ]

    Gene ID: 421202, updated on 3-Dec-2024

    Summary

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    Symbol
    FANCLprovided by CGNC
    Full Name
    Fanconi anemia complementation group Lprovided by CGNC
    Primary source
    CGNC:5961
    See related
    Ensembl:ENSGALG00010017104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See FANCL in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (1003650..1032154, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (970148..998660, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532111 Neighboring gene microRNA 6583 Neighboring gene uncharacterized LOC121110468 Neighboring gene VRK serine/threonine kinase 2 Neighboring gene uncharacterized LOC101748294 Neighboring gene microRNA 7463 Neighboring gene uncharacterized LOC112532195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A requirement of FancL and FancD2 monoubiquitination in DNA repair. Seki S, et al. Genes Cells, 2007 Mar. PMID 17352736
    2. A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair. Matsushita N, et al. Mol Cell, 2005 Sep 16. PMID 16168378
    3. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Rosado IV, et al. Nat Struct Mol Biol, 2011 Nov 13. PMID 22081012
    4. DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Sato K, et al. Nucleic Acids Res, 2012 May. PMID 22287633, Free PMC Article
    5. Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. Sato K, et al. EMBO J, 2012 Aug 29. PMID 22828868, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase FANCL
    Names
    FA complementation group L
    Fanconi anemia protein FANCL
    NP_001029113.1
    XP_025004391.1
    XP_025004392.1
    XP_046769449.1
    XP_046769450.1
    XP_046769451.1
    XP_046769452.1
    XP_046769453.1
    XP_046769454.1
    XP_046769455.1
    XP_046769456.1
    XP_046769457.1
    XP_046769458.1
    XP_046794616.1
    XP_046794617.1
    XP_046794618.1
    XP_046794619.1
    XP_046794620.1
    XP_046794621.1
    XP_046794622.1
    XP_046794623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033941.2 → NP_001029113.1  E3 ubiquitin-protein ligase FANCL

      See identical proteins and their annotated locations for NP_001029113.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000059
      UniProtKB/TrEMBL
      A0A8V0YZE4, Q3MUH5
      Related
      ENSGALP00010024177.1, ENSGALT00010041290.1
      Conserved Domains (4) summary
      pfam09765
      Location:6 → 92
      WD-3; WD-repeat region
      pfam11793
      Location:301 → 369
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:106 → 195
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:197 → 293
      FANCL_d3; FANCL UBC-like domain 3

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1003650..1032154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938666.1 → XP_046794622.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    2. XM_046938663.1 → XP_046794619.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    3. XM_025148624.3 → XP_025004392.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4
      Conserved Domains (3) summary
      pfam09765
      Location:3 → 243
      WD-3; WD-repeat region
      pfam11793
      Location:251 → 319
      FANCL_C; FANCL C-terminal domain
      cd16490
      Location:255 → 310
      RING-CH-C4HC3_FANCL; RING-CH finger (C4HC3-type) [structural motif]

    4. XM_046938661.1 → XP_046794617.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    5. XM_046938665.1 → XP_046794621.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    6. XM_046938662.1 → XP_046794618.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    7. XM_046938667.1 → XP_046794623.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    8. XM_025148623.3 → XP_025004391.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4
      Conserved Domains (3) summary
      pfam09765
      Location:9 → 251
      WD-3; WD-repeat region
      pfam11793
      Location:259 → 327
      FANCL_C; FANCL C-terminal domain
      cd16490
      Location:263 → 318
      RING-CH-C4HC3_FANCL; RING-CH finger (C4HC3-type) [structural motif]

    9. XM_046938664.1 → XP_046794620.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    10. XM_046938660.1 → XP_046794616.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      970148..998660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913501.1 → XP_046769457.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    2. XM_046913497.1 → XP_046769453.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    3. XM_046913498.1 → XP_046769454.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    4. XM_046913494.1 → XP_046769450.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    5. XM_046913500.1 → XP_046769456.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    6. XM_046913495.1 → XP_046769451.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    7. XM_046913502.1 → XP_046769458.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    8. XM_046913496.1 → XP_046769452.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4

    9. XM_046913499.1 → XP_046769455.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZE4

    10. XM_046913493.1 → XP_046769449.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZE4
    Nucleotide Protein Strain
    Heading Accession and Version

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