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    LIN28B lin-28 homolog B [ Gallus gallus (chicken) ]

    Gene ID: 421786, updated on 3-Dec-2024

    Summary

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    Symbol
    LIN28Bprovided by CGNC
    Full Name
    lin-28 homolog Bprovided by CGNC
    Primary source
    CGNC:66411
    See related
    Ensembl:ENSGALG00010013340
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See LIN28B in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (68589642..68683197, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (68370228..68463748, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene popeye domain containing 3 Neighboring gene blood vessel epicardial substance Neighboring gene HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC101751157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning. Bobbs AS, et al. J Biol Chem, 2012 Nov 9. PMID 22995917, Free PMC Article
    2. The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development. Lee SI, et al. Mol Reprod Dev, 2015 Dec. PMID 26297836
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development.
      Title: The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.
    2. FGF signaling regulates gene expression by negatively modulating microRNA abundance through both LIN28B-dependent and LIN28B-independent pathways
      Title: Fibroblast growth factor (FGF) signaling during gastrulation negatively modulates the abundance of microRNAs that regulate proteins required for cell migration and embryo patterning.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein lin-28 homolog B
    Names
    Lin-28.2
    lin-28B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034818.2 → NP_001029990.1  protein lin-28 homolog B

      See identical proteins and their annotated locations for NP_001029990.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000065
      UniProtKB/Swiss-Prot
      Q45KJ4
      UniProtKB/TrEMBL
      A0A8V0YJZ7
      Related
      ENSGALP00010018902.1, ENSGALT00010032112.1
      Conserved Domains (2) summary
      COG5082
      Location:102 → 188
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      cd04458
      Location:32 → 101
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      68589642..68683197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015284527.4 → XP_015140013.1  protein lin-28 homolog B isoform X2

      UniProtKB/TrEMBL
      A0A8V0YJZ7
      Conserved Domains (2) summary
      COG5082
      Location:109 → 195
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      cd04458
      Location:39 → 108
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. XM_015284525.4 → XP_015140011.1  protein lin-28 homolog B isoform X1

      UniProtKB/TrEMBL
      A0A8V0YJZ7, A0A8V0YK01
      Related
      ENSGALP00010018904.1, ENSGALT00010032114.1
      Conserved Domains (2) summary
      COG5082
      Location:110 → 196
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      cd04458
      Location:40 → 109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    3. XM_015284528.4 → XP_015140014.1  protein lin-28 homolog B isoform X3

      UniProtKB/TrEMBL
      A0A8V0YJZ7
      Conserved Domains (2) summary
      COG5082
      Location:101 → 187
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      cd04458
      Location:31 → 100
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      68370228..68463748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046914049.1 → XP_046770005.1  protein lin-28 homolog B isoform X2

      UniProtKB/TrEMBL
      A0A8V0YJZ7

    2. XM_046914048.1 → XP_046770004.1  protein lin-28 homolog B isoform X1

      UniProtKB/TrEMBL
      A0A8V0YJZ7, A0A8V0YK01

    3. XM_046914050.1 → XP_046770006.1  protein lin-28 homolog B isoform X3

      UniProtKB/TrEMBL
      A0A8V0YJZ7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q45KJ4.1 GenPept UniProtKB/Swiss-Prot:Q45KJ4

    Gene LinkOut

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