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    TCF12 transcription factor 12 [ Gallus gallus (chicken) ]

    Gene ID: 396334, updated on 7-Dec-2024

    Summary

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    Symbol
    TCF12provided by CGNC
    Full Name
    transcription factor 12provided by CGNC
    Primary source
    CGNC:49756
    See related
    Ensembl:ENSGALG00010023170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TCF12 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (7424009..7610828, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (7296981..7483774, complement)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052129 Neighboring gene aldehyde dehydrogenase 1 family member A2 Neighboring gene myocardial zonula adherens protein Neighboring gene cingulin like 1 Neighboring gene zinc finger protein 280D Neighboring gene testis expressed 9 Neighboring gene meiosis specific nuclear structural 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CTF4, a chicken transcription factor of the helix-loop-helix class A family. Tsay HJ, et al. Nucleic Acids Res, 1992 Apr 11. PMID 1579475, Free PMC Article
    2. Cloning and analysis of a new developmentally regulated member of the basic helix-loop-helix family. Helms JA, et al. Mech Dev, 1994 Nov. PMID 7873406
    3. ME1 and GE1: basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions. Neuman T, et al. Eur J Neurosci, 1993 Apr 1. PMID 8261111
    4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 12
    Names
    E-box-binding protein
    TCF-12
    basic helix-loop-helix protein
    class A helix-loop-helix transcription factor GE1
    transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)
    transcription factor HTF-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205375.4 → NP_990706.2  transcription factor 12

      Status: PROVISIONAL

      Source sequence(s)
      BX935683, JAENSK010000245, U12974
      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      smart00353
      Location:508 → 561
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7424009..7610828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040706208.2 → XP_040562142.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8
      Conserved Domains (1) summary
      cd18945
      Location:621 → 705
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    2. XM_040706218.2 → XP_040562152.1  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8
      Related
      ENSGALP00010034221.1, ENSGALT00010056478.1
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    3. XM_040706220.2 → XP_040562154.1  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    4. XM_040706214.2 → XP_040562148.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:597 → 681
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    5. XM_040706206.2 → XP_040562140.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8
      Related
      ENSGALP00010034223.1, ENSGALT00010056480.1
      Conserved Domains (1) summary
      cd18945
      Location:621 → 705
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    6. XM_040706216.2 → XP_040562150.1  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    7. XM_040706219.2 → XP_040562153.1  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    8. XM_040706213.2 → XP_040562147.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:597 → 681
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    9. XM_040706210.2 → XP_040562144.1  transcription factor 12 isoform X2

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:620 → 704
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    10. XM_040706211.2 → XP_040562145.1  transcription factor 12 isoform X3

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRS1
      Related
      ENSGALP00010034226.1, ENSGALT00010056483.1
      Conserved Domains (1) summary
      cd18945
      Location:620 → 704
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    11. XM_025153805.3 → XP_025009573.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8
      Conserved Domains (1) summary
      cd18945
      Location:621 → 705
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    12. XM_040706221.2 → XP_040562155.1  transcription factor 12 isoform X8

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:595 → 679
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    13. XM_015278769.4 → XP_015134255.2  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    14. XM_015278770.4 → XP_015134256.2  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:596 → 680
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    15. XM_015278768.4 → XP_015134254.2  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:597 → 681
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    16. XM_046898939.1 → XP_046754895.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    17. XM_015278766.4 → XP_015134252.2  transcription factor 12 isoform X2

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:620 → 704
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    18. XM_015278764.4 → XP_015134250.2  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8
      Conserved Domains (1) summary
      cd18945
      Location:621 → 705
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    19. XM_046898938.1 → XP_046754894.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    20. XM_046898940.1 → XP_046754896.1  transcription factor 12 isoform X5

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    21. XM_040706222.2 → XP_040562156.1  transcription factor 12 isoform X9

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      Conserved Domains (1) summary
      cd18945
      Location:571 → 655
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    22. XM_040706229.2 → XP_040562163.1  transcription factor 12 isoform X17

      Conserved Domains (1) summary
      cd18945
      Location:388 → 472
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    23. XM_040706225.2 → XP_040562159.1  transcription factor 12 isoform X12

      Conserved Domains (1) summary
      cd18945
      Location:412 → 496
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    24. XM_040706228.2 → XP_040562162.1  transcription factor 12 isoform X16

      Conserved Domains (1) summary
      cd18945
      Location:403 → 487
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    25. XM_046898941.1 → XP_046754897.1  transcription factor 12 isoform X14

    26. XM_040706223.2 → XP_040562157.1  transcription factor 12 isoform X11

      UniProtKB/TrEMBL
      A0A8V0ZRR3
      Related
      ENSGALP00010034216.1, ENSGALT00010056473.1
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    27. XM_015278773.4 → XP_015134259.1  transcription factor 12 isoform X15

      Conserved Domains (1) summary
      smart00353
      Location:415 → 468
      HLH; helix loop helix domain

    28. XM_015278772.4 → XP_015134258.1  transcription factor 12 isoform X13

      Conserved Domains (1) summary
      cd18945
      Location:404 → 488
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    29. XM_040706227.2 → XP_040562161.1  transcription factor 12 isoform X13

      Conserved Domains (1) summary
      cd18945
      Location:404 → 488
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    30. XM_015278771.3 → XP_015134257.1  transcription factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZTR0
      Related
      ENSGALP00010034213.1, ENSGALT00010056470.1
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    31. XM_040706224.2 → XP_040562158.1  transcription factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZTR0
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    32. XM_040706232.2 → XP_040562166.2  transcription factor 12 isoform X20

    33. XM_040706231.2 → XP_040562165.2  transcription factor 12 isoform X19

    34. XM_040706230.2 → XP_040562164.2  transcription factor 12 isoform X18

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7296981..7483774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924558.1 → XP_046780514.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    2. XM_046924569.1 → XP_046780525.1  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8

    3. XM_046924572.1 → XP_046780528.1  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    4. XM_046924564.1 → XP_046780520.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    5. XM_046924556.1 → XP_046780512.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    6. XM_046924568.1 → XP_046780524.1  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8

    7. XM_046924571.1 → XP_046780527.1  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    8. XM_046924563.1 → XP_046780519.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    9. XM_046924559.1 → XP_046780515.1  transcription factor 12 isoform X2

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    10. XM_046924561.1 → XP_046780517.1  transcription factor 12 isoform X3

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRS1

    11. XM_046924555.1 → XP_046780511.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    12. XM_046924573.1 → XP_046780529.1  transcription factor 12 isoform X8

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    13. XM_046924567.1 → XP_046780523.1  transcription factor 12 isoform X6

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZRR8

    14. XM_046924570.1 → XP_046780526.1  transcription factor 12 isoform X7

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    15. XM_046924562.1 → XP_046780518.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    16. XM_046924565.1 → XP_046780521.1  transcription factor 12 isoform X4

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    17. XM_046924560.1 → XP_046780516.1  transcription factor 12 isoform X2

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    18. XM_046924554.1 → XP_046780510.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    19. XM_046924557.1 → XP_046780513.1  transcription factor 12 isoform X1

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1
      UniProtKB/TrEMBL
      A0A8V0ZTR8

    20. XM_046924566.1 → XP_046780522.1  transcription factor 12 isoform X5

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    21. XM_046924574.1 → XP_046780530.1  transcription factor 12 isoform X9

      UniProtKB/Swiss-Prot
      P30985, Q90622, Q9PSH1

    22. XM_046924584.1 → XP_046780540.1  transcription factor 12 isoform X17

    23. XM_046924578.1 → XP_046780534.1  transcription factor 12 isoform X12

    24. XM_046924583.1 → XP_046780539.1  transcription factor 12 isoform X16

    25. XM_046924580.1 → XP_046780536.1  transcription factor 12 isoform X14

    26. XM_046924576.1 → XP_046780532.1  transcription factor 12 isoform X11

      UniProtKB/TrEMBL
      A0A8V0ZRR3

    27. XM_046924582.1 → XP_046780538.1  transcription factor 12 isoform X15

    28. XM_046924579.1 → XP_046780535.1  transcription factor 12 isoform X13

    29. XM_046924581.1 → XP_046780537.1  transcription factor 12 isoform X13

    30. XM_046924575.1 → XP_046780531.1  transcription factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZTR0

    31. XM_046924577.1 → XP_046780533.1  transcription factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZTR0

    32. XM_046924588.1 → XP_046780544.1  transcription factor 12 isoform X20

    33. XM_046924587.1 → XP_046780543.1  transcription factor 12 isoform X19

    34. XM_046924585.1 → XP_046780541.1  transcription factor 12 isoform X18

    35. XM_046924586.1 → XP_046780542.1  transcription factor 12 isoform X21

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30985.2 GenPept UniProtKB/Swiss-Prot:P30985

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