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    LTK leukocyte receptor tyrosine kinase [ Gallus gallus (chicken) ]

    Gene ID: 423216, updated on 3-Dec-2024

    Summary

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    Symbol
    LTKprovided by CGNC
    Full Name
    leukocyte receptor tyrosine kinaseprovided by CGNC
    Primary source
    CGNC:51922
    See related
    Ensembl:ENSGALG00010022572
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See LTK in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (24232470..24370567, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (24199933..24337980, complement)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110829 Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene carbohydrate sulfotransferase 9-like Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene RNA polymerase II associated protein 1 Neighboring gene transmembrane protein 151B-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system. Hurley SP, et al. J Comp Neurol, 2006 Mar 10. PMID 16435287, Free PMC Article
    2. Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells. Vieceli FM, et al. Development, 2018 Oct 24. PMID 30228102, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LTK in neural crest cells interacts with midkine emanating from the non-neural ectoderm to promote cell survival.
      Title: Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells.
    2. the data presented here identify ALK as a novel candidate receptor for regulating critical events in the development of neurons in both the central and the peripheral nervous systems.
      Title: Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leukocyte tyrosine kinase receptor
    Names
    leukocyte tyrosine kinase
    XP_004941681.2
    XP_040527924.1
    XP_040527925.1
    XP_040557085.1
    XP_046775648.1
    XP_046798613.1
    XP_046798614.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      24232470..24370567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040701151.2 → XP_040557085.1  leukocyte tyrosine kinase receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZP30, A0A8V0ZRL2
      Related
      ENSGALP00010033232.1, ENSGALT00010054964.1
      Conserved Domains (2) summary
      cd06263
      Location:314 → 470
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd05036
      Location:951 → 1227
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    2. XM_046942657.1 → XP_046798613.1  leukocyte tyrosine kinase receptor isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZP24
      Related
      ENSGALP00010033222.1, ENSGALT00010054949.1

    3. XM_004941624.5 → XP_004941681.2  leukocyte tyrosine kinase receptor isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZIP9, A0A8V0ZP24
      Related
      ENSGALP00010033219.1, ENSGALT00010054943.1
      Conserved Domains (2) summary
      cd06263
      Location:282 → 438
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd05036
      Location:919 → 1195
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    4. XM_046942658.1 → XP_046798614.1  leukocyte tyrosine kinase receptor isoform X4

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      24199933..24337980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040671990.2 → XP_040527924.1  leukocyte tyrosine kinase receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZRL2
      Conserved Domains (2) summary
      cd06263
      Location:308 → 464
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd05036
      Location:945 → 1221
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    2. XM_046919692.1 → XP_046775648.1  leukocyte tyrosine kinase receptor isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZP24

    3. XM_040671991.2 → XP_040527925.1  leukocyte tyrosine kinase receptor isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZP24
      Conserved Domains (2) summary
      cd06263
      Location:282 → 438
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd05036
      Location:919 → 1195
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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