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    MMP16 matrix metallopeptidase 16 [ Gallus gallus (chicken) ]

    Gene ID: 396116, updated on 3-Dec-2024

    Summary

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    Symbol
    MMP16provided by CGNC
    Full Name
    matrix metallopeptidase 16provided by CGNC
    Primary source
    CGNC:49658
    See related
    Ensembl:ENSGALG00010012390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    MT3-MMP
    Orthologs
    human mouse all
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    Genomic context

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    See MMP16 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (123254491..123430269, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (123447538..123623560, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110000 Neighboring gene uncharacterized LOC121110002 Neighboring gene uncharacterized LOC121110001 Neighboring gene uncharacterized LOC121110007 Neighboring gene receptor interacting serine/threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration. Roth L, et al. Int J Dev Biol, 2017. PMID 28621422
    2. Cloning and developmental expression of a membrane-type matrix metalloproteinase from chicken. Yang M, et al. J Biol Chem, 1996 Oct 11. PMID 8810327
    3. Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation. Jung JC, et al. Cell Tissue Res, 2009 Apr. PMID 19221802, Free PMC Article
    4. Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. Huh MI, et al. J Cell Biochem, 2007 Aug 1. PMID 17295208
    5. EST analysis of mRNAs expressed during embryogenesis in Gallus gallus. Jorge EC, et al. Int J Dev Biol, 2004 Jun. PMID 15300514

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MMP16 is a new effector participating in epithelial-to-mesenchymal-transition and in the migration of neural crest cells
      Title: A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration.
    2. MMP-2/MT3-MMP are involved in the initiation and progression of fibril growth, matrix assembly, and tendon development.
      Title: Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation.
    3. These findings collectively show for the first time that multiple MMPs, ADAMs, and TIMPs appear to functionally interact during corneal development.
      Title: Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix metalloproteinase-16
    Names
    matrix metallopeptidase 16 (membrane-inserted)
    matrix metalloproteinase 16 (membrane-inserted)
    membrane type-matrix metalloproteinase
    NP_990528.2
    XP_025002826.1
    XP_046766382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205197.3 → NP_990528.2  matrix metalloproteinase-16

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000044
      UniProtKB/TrEMBL
      A0A1D5PZ77, A0A8V0YEB1
      Related
      ENSGALP00010017270.1, ENSGALT00010029680.1
      Conserved Domains (5) summary
      cd00094
      Location:342 → 534
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:126 → 291
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:126 → 291
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 96
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:539 → 609
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      123254491..123430269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025147058.3 → XP_025002826.1  matrix metalloproteinase-16 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YEB1
      Conserved Domains (4) summary
      cd00094
      Location:342 → 493
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:126 → 291
      Peptidase_M10; Matrixin
      pfam01471
      Location:42 → 96
      PG_binding_1; Putative peptidoglycan binding domain
      cl26464
      Location:273 → 353
      Atrophin-1; Atrophin-1 family

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      123447538..123623560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910426.1 → XP_046766382.1  matrix metalloproteinase-16 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YEB1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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