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    TWIST2 twist family bHLH transcription factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 395405, updated on 17-Aug-2024

    Summary

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    Symbol
    TWIST2provided by CGNC
    Full Name
    twist family bHLH transcription factor 2provided by CGNC
    Primary source
    CGNC:49300
    See related
    Ensembl:ENSGALG00010013612
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CDERMO-1
    Orthologs
    human mouse all
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    Genomic context

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    See TWIST2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (6190698..6221121)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (6131840..6162266)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111299 Neighboring gene pancreas transcription factor 1 subunit alpha-like Neighboring gene uncharacterized LOC121111300 Neighboring gene uncharacterized LOC121111278 Neighboring gene histone deacetylase 4 Neighboring gene uncharacterized LOC107053773 Neighboring gene uncharacterized LOC121111301

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDermo-1 expression indicates a role in avian skin development. Scaal M, et al. Anat Embryol (Berl), 2001 Jan. PMID 11195085
    2. Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1. Wade C, et al. Dev Biol, 2012 Oct 1. PMID 22884497
    3. Evolution of the vertebrate twist family and synfunctionalization: a mechanism for differential gene loss through merging of expression domains. Gitelman I. Mol Biol Evol, 2007 Sep. PMID 17567594
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
      Title: Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twist-related protein 2
    Names
    dermo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204679.2 → NP_990010.1  twist-related protein 2

      See identical proteins and their annotated locations for NP_990010.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000235
      UniProtKB/TrEMBL
      Q9YH69
      Related
      ENSGALP00010019389.1, ENSGALT00010032725.1
      Conserved Domains (1) summary
      cl00081
      Location:51 → 132
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      6190698..6221121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015289113.4 → XP_015144599.1  twist-related protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9YH69
      Related
      ENSGALP00010019377.1, ENSGALT00010032706.1
      Conserved Domains (1) summary
      cl00081
      Location:51 → 132
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RNA

    1. XR_006939788.1 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      6131840..6162266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921013.1 → XP_046776969.1  twist-related protein 2 isoform X1

      UniProtKB/TrEMBL
      Q9YH69

    RNA

    1. XR_006935207.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials