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    HBAD hemoglobin alpha, subunit D [ Gallus gallus (chicken) ]

    Gene ID: 416651, updated on 17-Aug-2024

    Summary

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    Symbol
    HBADprovided by CGNC
    Full Name
    hemoglobin alpha, subunit Dprovided by CGNC
    Primary source
    CGNC:50309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    HBM; HBA2
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    Genomic context

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    See HBAD in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (12115577..12116504)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (12111215..12112142)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene nitrogen permease regulator-like 3 (S. cerevisiae) Neighboring gene hemoglobin subunit zeta Neighboring gene hemoglobin subunit alpha 1 Neighboring gene transmembrane protein 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid sequence of the alpha chain of chicken AI hemoglobin. Takei H, et al. J Biochem, 1975 Jun. PMID 1225908
    2. Indefinite noncooperative self-association of chicken deoxy hemoglobin D. Rana MS, et al. Proteins, 2011 May. PMID 21337627
    3. Study of spatial organization of chicken alpha-globin gene domain by 3C technique. Gavrilov AA, et al. Biochemistry (Mosc), 2008 Nov. PMID 19120022
    4. The structural and functional analysis of the hemoglobin D component from chicken. Knapp JE, et al. J Biol Chem, 1999 Mar 5. PMID 10037733
    5. Minor early embryonic chick hemoglobin M. Amino acid sequences of the epsilon and alpha D chains. Chapman BS, et al. J Biol Chem, 1982 Jan 25. PMID 7054172

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this model, the deoxy hemoglobin D associates noncooperatively to give a linear oligomeric chain with an equilibrium association constant of 1.42 x 10(4) M(-1) at 20 degrees C for each step.
      Title: Indefinite noncooperative self-association of chicken deoxy hemoglobin D.
    2. Spatial organization of the chicken HBA2 and HBA1 gene domains is different in erythroid and non-erythroid cells.
      Title: Study of spatial organization of chicken alpha-globin gene domain by 3C technique.
    3. in avian erythroblastosis virus-transformed chicken erythroleukaemic cells, where globin gene expression is abortive, the whole domain of alpha-globin genes is transcribed for about 33 kb in the globin direction and this RNA is part of the nuclear matrix
      Title: The 33 kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables haptoglobin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables organic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of haptoglobin-hemoglobin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of hemoglobin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hemoglobin subunit alpha-D
    Names
    adult alpha D globin
    alpha-D-globin
    hemoglobin alpha-D chain
    hemoglobin subunit mu
    hemoglobin, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004375.3 → NP_001004375.1  hemoglobin subunit alpha-D

      See identical proteins and their annotated locations for NP_001004375.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000257
      UniProtKB/Swiss-Prot
      P02001, Q549K7, Q78AJ9
      Conserved Domains (1) summary
      cd08927
      Location:2 → 141
      Hb-alpha-like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12115577..12116504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12111215..12112142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02001.1 GenPept UniProtKB/Swiss-Prot:P02001

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.