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    TOP3B topoisomerase (DNA) III beta [ Gallus gallus (chicken) ]

    Gene ID: 416771, updated on 3-Dec-2024

    Summary

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    Symbol
    TOP3Bprovided by CGNC
    Full Name
    topoisomerase (DNA) III betaprovided by CGNC
    Primary source
    CGNC:1026
    See related
    Ensembl:ENSGALG00010024339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TOP3B in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (473596..487405)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (479168..492977)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene microRNA 301a Neighboring gene microRNA 130a Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene uncharacterized LOC121106876 Neighboring gene mitogen-activated protein kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids. Seki M, et al. Mol Cell Biol, 2006 Aug. PMID 16880537, Free PMC Article
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 3-beta-1
    Names
    DNA topoisomerase III beta
    NP_001006181.1
    XP_015130719.1
    XP_015130721.1
    XP_015130722.1
    XP_046784047.1
    XP_046784048.1
    XP_046784049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006181.1 → NP_001006181.1  DNA topoisomerase 3-beta-1

      See identical proteins and their annotated locations for NP_001006181.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ720213
      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71
      Related
      ENSGALP00010036231.1, ENSGALT00010059355.1
      Conserved Domains (3) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      cd00186
      Location:173 → 593
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam01131
      Location:169 → 583
      Topoisom_bac; DNA topoisomerase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      473596..487405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015275233.4 → XP_015130719.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71
      Related
      ENSGALP00010036229.1, ENSGALT00010059353.1
      Conserved Domains (3) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      cd00186
      Location:173 → 593
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam01131
      Location:169 → 583
      Topoisom_bac; DNA topoisomerase

    2. XM_015275236.4 → XP_015130722.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71
      Conserved Domains (3) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      cd00186
      Location:173 → 593
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam01131
      Location:169 → 583
      Topoisom_bac; DNA topoisomerase

    3. XM_015275235.4 → XP_015130721.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71
      Conserved Domains (3) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
      cd00186
      Location:173 → 593
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
      pfam01131
      Location:169 → 583
      Topoisom_bac; DNA topoisomerase

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      479168..492977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046928091.1 → XP_046784047.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71

    2. XM_046928093.1 → XP_046784049.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71

    3. XM_046928092.1 → XP_046784048.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A153, Q5ZK71
    Nucleotide Protein Strain
    Heading Accession and Version

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