EGR1 early growth response 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: EGR1provided by CGNC
Official Full Name: early growth response 1provided by CGNC
Primary source: CGNC:48962
See related: Ensembl:ENSGALG00010016647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (17853197..17856289)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (17864159..17867251)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of histone deacetylases in the chick brain up-regulates the expression of c-Fos and ZENK transcription factors and facilitates establishment of long-term memory.
Title: [Inhibition of histone deacetylases in the chick brain modulates expression of c-Fos and ZENK transcription factors and facilitates establishment of long-term memory].
EGR1 and EGR2 involvement in vertebrate tendon differentiation.
Title: EGR1 and EGR2 involvement in vertebrate tendon differentiation.
The gene encoding the transcription factor EGR1 was downregulated in the non-metastatic PR9692-E9 cells.
Title: The transcription factor EGR1 regulates metastatic potential of v-src transformed sarcoma cells.
Both form-deprivation and negative-lens wear modulated the retinal expression of ZENK and PPG RNA transcripts, with a similar time-course and strength of response.
Title: Alterations in ZENK and glucagon RNA transcript expression during increased ocular growth in chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: early growth response protein 1

Names: EGR-1; zinc finger protein ZENK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204136.3 → NP_989467.3 early growth response protein 1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000256

UniProtKB/TrEMBL

Q5ZLU9, Q8QG62

Related

ENSGALP00010023267.1, ENSGALT00010040141.1

Conserved Domains (5) summary

COG5189
Location:269 → 388

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:312 → 334

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam11914
Location:426 → 497

DUF3432; Domain of unknown function (DUF3432)

pfam11928
Location:111 → 181

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:354 → 379

zf-H2C2_2; Zinc-finger double domain