U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ARHGEF18 Rho guanine nucleotide exchange factor 18 [ Gallus gallus (chicken) ]

    Gene ID: 420132, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ARHGEF18provided by CGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 18provided by CGNC
    Primary source
    CGNC:2608
    See related
    Ensembl:ENSGALG00010027244
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ARHGEF18 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (4518117..4559085, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (4080331..4121280, complement)

    Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene ectoderm-neural cortex protein 1-like Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene uncharacterized LOC124417446 Neighboring gene uncharacterized LOC121107760 Neighboring gene insulin receptor Neighboring gene unconventional SNARE in the ER 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    rho guanine nucleotide exchange factor 18
    Names
    Rho/Rac guanine nucleotide exchange factor (GEF) 18
    Rho/Rac guanine nucleotide exchange factor 18

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4518117..4559085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015300163.4 → XP_015155649.2  rho guanine nucleotide exchange factor 18 isoform X6

      Conserved Domains (4) summary
      smart00109
      Location:389 → 435
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:590 → 784
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:824 → 942
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1128 → 1285
      DUF5401; Family of unknown function (DUF5401)

    2. XM_040653794.2 → XP_040509728.1  rho guanine nucleotide exchange factor 18 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A360
      Related
      ENSGALP00010040318.1, ENSGALT00010066052.1
      Conserved Domains (4) summary
      smart00109
      Location:437 → 483
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:638 → 832
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:872 → 990
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1176 → 1333
      DUF5401; Family of unknown function (DUF5401)

    3. XM_040653796.2 → XP_040509730.1  rho guanine nucleotide exchange factor 18 isoform X5

      Conserved Domains (3) summary
      cd00160
      Location:597 → 791
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:831 → 949
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1135 → 1292
      DUF5401; Family of unknown function (DUF5401)

    4. XM_040653795.2 → XP_040509729.1  rho guanine nucleotide exchange factor 18 isoform X4

      Conserved Domains (3) summary
      cd00160
      Location:598 → 792
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:832 → 950
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1136 → 1293
      DUF5401; Family of unknown function (DUF5401)

    5. XM_015300162.4 → XP_015155648.2  rho guanine nucleotide exchange factor 18 isoform X2

      Conserved Domains (4) summary
      smart00109
      Location:455 → 501
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:655 → 849
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:889 → 1007
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1193 → 1350
      DUF5401; Family of unknown function (DUF5401)

    6. XM_418249.8 → XP_418249.5  rho guanine nucleotide exchange factor 18 isoform X1

      UniProtKB/TrEMBL
      A0A8V1AFK2
      Related
      ENSGALP00010040319.1, ENSGALT00010066053.1
      Conserved Domains (4) summary
      smart00109
      Location:455 → 501
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:656 → 850
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:890 → 1008
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1194 → 1351
      DUF5401; Family of unknown function (DUF5401)

    7. XM_040653799.1 → XP_040509733.1  rho guanine nucleotide exchange factor 18 isoform X7

      Conserved Domains (3) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:640 → 797
      DUF5401; Family of unknown function (DUF5401)

    8. XM_040653797.1 → XP_040509731.1  rho guanine nucleotide exchange factor 18 isoform X7

      Conserved Domains (3) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:640 → 797
      DUF5401; Family of unknown function (DUF5401)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4080331..4121280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040692951.2 → XP_040548885.1  rho guanine nucleotide exchange factor 18 isoform X6

      Conserved Domains (4) summary
      smart00109
      Location:389 → 435
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:590 → 784
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:824 → 942
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1128 → 1285
      DUF5401; Family of unknown function (DUF5401)

    2. XM_040692948.2 → XP_040548882.1  rho guanine nucleotide exchange factor 18 isoform X3

      Conserved Domains (4) summary
      smart00109
      Location:437 → 483
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:638 → 832
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:872 → 990
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1176 → 1333
      DUF5401; Family of unknown function (DUF5401)

    3. XM_040692950.2 → XP_040548884.1  rho guanine nucleotide exchange factor 18 isoform X5

      Conserved Domains (3) summary
      cd00160
      Location:597 → 791
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:831 → 949
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1135 → 1292
      DUF5401; Family of unknown function (DUF5401)

    4. XM_040692949.2 → XP_040548883.1  rho guanine nucleotide exchange factor 18 isoform X4

      Conserved Domains (3) summary
      cd00160
      Location:598 → 792
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:832 → 950
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1136 → 1293
      DUF5401; Family of unknown function (DUF5401)

    5. XM_040692947.2 → XP_040548881.1  rho guanine nucleotide exchange factor 18 isoform X2

      Conserved Domains (4) summary
      smart00109
      Location:455 → 501
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:655 → 849
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:889 → 1007
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1193 → 1350
      DUF5401; Family of unknown function (DUF5401)

    6. XM_040692946.2 → XP_040548880.1  rho guanine nucleotide exchange factor 18 isoform X1

      Conserved Domains (4) summary
      smart00109
      Location:455 → 501
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:656 → 850
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:890 → 1008
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:1194 → 1351
      DUF5401; Family of unknown function (DUF5401)

    7. XM_040692953.1 → XP_040548887.1  rho guanine nucleotide exchange factor 18 isoform X7

      Conserved Domains (3) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:640 → 797
      DUF5401; Family of unknown function (DUF5401)

    8. XM_040692952.1 → XP_040548886.1  rho guanine nucleotide exchange factor 18 isoform X7

      Conserved Domains (3) summary
      cd00160
      Location:102 → 296
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd15794
      Location:336 → 454
      PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
      pfam17380
      Location:640 → 797
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials