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    IRF1 interferon regulatory factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 396384, updated on 3-Dec-2024

    Summary

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    Official Symbol
    IRF1provided by CGNC
    Official Full Name
    interferon regulatory factor 1provided by CGNC
    Primary source
    CGNC:5120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See IRF1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16493644..16499641, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16505431..16511434, complement)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 4 Neighboring gene microRNA 1609-1 Neighboring gene solute carrier family 22 member 5 Neighboring gene interleukin 5 Neighboring gene RAD50 double strand break repair protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-β production. Liu Y, et al. Dev Comp Immunol, 2018 Nov. PMID 29981306
    2. Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family. Jungwirth C, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7536924, Free PMC Article
    3. UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway. Wang X, et al. Vet Microbiol, 2024 Apr. PMID 38387235
    4. Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34. Avery S, et al. J Interferon Cytokine Res, 2004 Oct. PMID 15626157
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
      Title: UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
    2. these studies demonstrate that chIRF1 is an important regulator of IFN-beta and is involved in chicken antiviral innate immunity.
      Title: Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-β production.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon regulatory factor 1
    Names
    IRF-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205415.2 → NP_990746.1  interferon regulatory factor 1

      See identical proteins and their annotated locations for NP_990746.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000256
      UniProtKB/Swiss-Prot
      Q5W4T4, Q90876
      UniProtKB/TrEMBL
      A0A8V0YVG0, M4M675
      Conserved Domains (1) summary
      pfam00605
      Location:7 → 112
      IRF; Interferon regulatory factor transcription factor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      16493644..16499641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294015.3 → XP_015149501.2  interferon regulatory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YVG0
      Conserved Domains (1) summary
      cd00103
      Location:5 → 113
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

    2. XM_046900312.1 → XP_046756268.1  interferon regulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5W4T4, Q90876
      UniProtKB/TrEMBL
      A0A8V0YVG0, M4M675

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      16505431..16511434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926881.1 → XP_046782837.1  interferon regulatory factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YVG0

    2. XM_046926880.1 → XP_046782836.1  interferon regulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5W4T4, Q90876
      UniProtKB/TrEMBL
      A0A8V0YVG0, M4M675
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90876.1 GenPept UniProtKB/Swiss-Prot:Q90876

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials